Trial reportScientific reports2026
Targeting individual pain catastrophizing to reduce migraine-related disability: a randomized controlled proof-of-concept trial using an online CBT intervention.
Trial report in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
This mechanistic randomized controlled proof-of-concept trial (RCT) investigated whether a brief online Cognitive Behavioral Therapy (CBT)-based avatar intervention can reduce individual pain catastrophizing in individuals with migraine and examined whether reductions in individual pain catastrophizing are associated with decreased migraine-related disability. Migraine is a highly disabling disorder, yet the mechanisms underlying migraine-related disability remain poorly understood. The Fear Avoidance Model (FAM) and recent research suggest that pain catastrophizing is a key mediator linking migraine experience with disability. A total of N = 55 individuals with migraine and ≥ 4 migraine days/month were randomized to either an intervention group (receiving cognitive restructuring targeting individual pain catastrophizing statements), or an active control group (contradicting false statements about migraine). Assessments at baseline, post-intervention, and six-week follow-up included individual Pain Catastrophizing (PCS-3), Headache Impact Test (HIT-6), as well as migraine-related and clinical characteristics. Intervention was evaluated using linear mixed-effects model. Hierarchical regression was used to determine the predictive effect of reductions in pain catastrophizing on reductions in disability. The intervention group demonstrated significantly greater reductions in pain catastrophizing at post-intervention (p = 0.009), while group differences diminished by follow-up. Decreases in individual pain catastrophizing were associated with reductions in migraine-related disability in both groups, explaining 24% of the variance (R
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.