Evidence map›Paper›PMID 42675145›Full record

ArticleScientific reports2026

Polyphenols intake and expression of insulin signaling genes in adipose tissue of obese adults: a cross-sectional study.

Farinaz Hosseini Balam, Faraneh Zolfaghari, Farshad Teymoori, Maryam Mousavi, Golaleh Asghari, Emad Yuzbashian, Alireza Khalaj, Mehdi Hedayati, Maryam Zarkesh, Atoosa Saidpour

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Article in Scientific reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors.

Farinaz Hosseini Balam *Department of Cellular and Molecular Nutrition, Faculty of Nutrition Science and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Faraneh ZolfaghariDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, P.O. Box: 193954741, Tehran, Iran.
Farshad Teymoori *Gastrointestinal and Liver Diseases Research Center, Iran University of Medical Sciences, Tehran, Iran.
Maryam MousaviDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, P.O. Box: 193954741, Tehran, Iran.
Golaleh AsghariDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Emad YuzbashianDepartment of Agriculture, Food and Nutritional Science, University of Alberta, Edmonton, AB, T6G 2P5, Canada.
Alireza KhalajDepartment of Surgery, Faculty of Medicine, Tehran Obesity Treatment Center, Shahed University, Tehran, Iran.
Mehdi HedayatiCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran.
Maryam ZarkeshCellular and Molecular Endocrine Research Center, Research Institute for Endocrine Molecular Biology, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences, P.O. Box: 19395-4763, Tehran, Iran. zarkesh@sbmu.ac.ir.
Atoosa SaidpourDepartment of Clinical Nutrition and Dietetics, Faculty of Nutrition and Food Technology, National Nutrition and Food Technology Research Institute, Shahid Beheshti University of Medical Sciences, P.O. Box: 193954741, Tehran, Iran. atoosa.saidpour@gmail.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Evidence suggests that polyphenol-rich diets enhance insulin sensitivity; however, their molecular mechanisms in human adipose tissue remain incompletely understood. We investigated whether habitual intake of total polyphenols and their major subclasses is associated with the expression of PI3K, Akt, and PTEN, key components of the PI3K/Akt insulin-signaling pathway, in visceral and subcutaneous adipose tissue (VAT and SAT) of adults with obesity, and how these associations relate to markers of insulin sensitivity. In this cross-sectional study, 135 adults with obesity (BMI ≥ 30 kg/m

Indexed as

Adipose TissueInsulinObesityPolyphenolsSignal TransductionAdultAgedCross-Sectional StudiesFemaleGene Expression RegulationHumansInsulin ResistanceIntra-Abdominal FatMaleMiddle AgedPhosphatidylinositol 3-KinasesInsulinPhosphatidylinositol 3-KinasesPolyphenolsProto-Oncogene Proteins c-aktPTEN PhosphohydrolasePTEN protein, humanAdipose tissueAktAnthocyaninsFlavanonesFlavonesFlavonoidsFlavonolsInsulin sensitivityObesityPI3KPTENTotal phenolic acids

Identifiers

PMID42675145
PMCPMC13530148

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.