ReviewPediatric research2026
Climate change, environmental exposures, and pediatric asthma exacerbations: air pollution, temperature, and relative humidity.
Review in Pediatric research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
0 citing papers in PubMed.
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Corrections and comments
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Authors and funding
9 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The prevalence of pediatric asthma exacerbations (AEs) has risen alongside climate change, yet how climate change modifies these exposures to raise pediatric AEs remains unclear. This review synthesizes epidemiological and mechanistic evidence on the contribution of air pollution, temperature, and relative humidity (RH) to pediatric AEs under climate change, drawing on a narrative search of PubMed and Web of Science (2000-2025) prioritizing systematic reviews, epidemiological studies, and climate-attribution/modeling studies. Climate change intensifies environmental drivers of AEs, to which children's higher ventilation and reactive airways heighten susceptibility. Air pollutants trigger oxidative stress, epithelial injury, and type 2 inflammation, while rising temperatures and extreme weather increase oxidative stress, C-fiber activation, and systemic inflammation. Climate-driven shifts in RH cause airway dehydration at low humidity and impaired mucus clearance at high humidity. Lengthening pollen seasons, transitional-weather viral circulation, and more frequent wildfires, hurricanes, floods, and dust storms further increase exacerbation risk. Climate-driven environmental changes contribute to pediatric AEs, though attribution is quantified for only selected exposures. Prevention strategies, including heat- and air-quality warning systems, environmental adaptation, and equity-focused targeting of high-risk populations, are needed. IMPACT: Climate change amplifies environmental triggers of pediatric asthma exacerbations, a burden concentrated among disadvantaged children by socioeconomic and structural disparities. Children's physiological vulnerability heightens their sensitivity to these triggers. Closing pediatric-specific attribution gaps and integrating climate-adaptation strategies into asthma care could reduce this burden.
Identifiers
42675131What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.