Evidence map›Paper›PMID 42675026›Full record

ArticlemAbs2026

Artificial intelligence-assisted design of MAGE-A4 ×CD16 T-cell receptor-like natural killer cell engagers.

Yang Liu, Hongsen Peng, Xing Fan, Xiaoxi Liu, Guanda Jiao, Jialin Li, Tiantian Wang, Simon James Fong, Lipeng Zhu, Yeneng Dai and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in mAbs, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Yang LiuDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Hongsen PengDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Xing FanDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Xiaoxi LiuDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Guanda JiaoDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Jialin LiDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Tiantian WangDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Simon James FongComputer and Information Science Department, Faculty of Science and Technology, University of Macau, Macau SAR, China.
Lipeng ZhuSchool of Life Sciences, Central South University, Changsha, China.
Yeneng DaiDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.
Qi ZhaoDepartment of Biomedical Science, Faculty of Medicine, University of Macau, Macau SAR, China.ORCID 0000-0002-5969-6407

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The cancer-testis antigen MAGE-A4 is an attractive immunotherapy target due to its high expression in various malignancies and restricted expression in normal tissues. Peptides derived from intracellular MAGE-A4 are presented on the cell surface by HLA-A*02:01, enabling targeting by T-cell receptor (TCR)-like molecules. We identified a TCR-like antibody recognizing the HLA-A *02:01-presented MAGE-A4 GVY230-239 peptide complex through yeast-display screening, computational structural prioritization, and experimental validation. Diverging from T-cell engagers, we engineered this binder into a natural killer cell engager (NKCE) by fusing it with a CD16-targeting variable domain of heavy-chain-only antibody (VHH) in an IgG format. This MAGE-A4-directed NKCE demonstrated potent and specific cytotoxicity against MAGE-A4

Indexed as

Antigens, NeoplasmKiller Cells, NaturalNeoplasm ProteinsReceptors, Antigen, T-CellReceptors, IgGCell Line, TumorGPI-Linked ProteinsHLA-A2 AntigenHumansAntigens, NeoplasmFCGR3B protein, humanGPI-Linked ProteinsHLA-A*02:01 antigenHLA-A2 AntigenMAGEA4 protein, humanNeoplasm ProteinsReceptors, Antigen, T-CellReceptors, IgGAIantibodybispecific antibodyNK cellTCR

Identifiers

PMID42675026
PMCPMC13532024

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.