Evidence map›Paper›PMID 42674818›Full record

ArticleCancer genomics & proteomics

Multi-omics Investigations of Immune Microenvironment of Human Colorectal Cancer.

Hongwei Zeng, Liewen Lin, Yumei Chen, Ligang Xia, Donge Tang, Yong Dai, Wei Zhang

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Article in Cancer genomics & proteomics. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Hongwei ZengDepartment of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, P.R. China.
Liewen LinGuangdong Provincial Autoimmune Disease Precision Medicine Engineering Research Center, Shenzhen Autoimmune Disease Engineering Research Center, Shenzhen Geriatrics Clinical Research Center, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China.
Yumei ChenGuangdong Provincial Autoimmune Disease Precision Medicine Engineering Research Center, Shenzhen Autoimmune Disease Engineering Research Center, Shenzhen Geriatrics Clinical Research Center, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China.
Ligang XiaGuangdong Provincial Autoimmune Disease Precision Medicine Engineering Research Center, Shenzhen Autoimmune Disease Engineering Research Center, Shenzhen Geriatrics Clinical Research Center, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China.
Donge TangGuangdong Provincial Autoimmune Disease Precision Medicine Engineering Research Center, Shenzhen Autoimmune Disease Engineering Research Center, Shenzhen Geriatrics Clinical Research Center, Shenzhen People's Hospital, Second Clinical Medical College of Jinan University, Shenzhen, P.R. China.
Yong DaiThe First Affiliated Hospital, School of Medicine, Anhui University of Science and Technology, Huainan, P.R. China.
Wei ZhangDepartment of Clinical Laboratory, Peking University Shenzhen Hospital, Shenzhen, P.R. China; w-z12@tsinghua.org.cn.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

BACKGROUND/

aimColorectal cancer (CRC) remains a leading cause of cancer-related morbidity and mortality worldwide. Although immunotherapy has improved outcomes for a subset of patients, its limited efficacy in many cases highlights the need for a more comprehensive understanding of the CRC immune microenvironment. This study aimed to characterize the molecular landscape of the CRC immune microenvironment using an integrated multi-omics approach and to identify candidate regulatory molecules associated with immune remodelling. MATERIALS AND

methodsWe integrated structural variation, DNA methylation, chromatin accessibility, proteomic, and phosphoproteomic data generated from an in-house CRC cohort with transcriptomic data from The Cancer Genome Atlas (TCGA). Analyses focused on 1,539 immune-related genes (IRGs) associated with CD4

resultsHigher infiltration of CD4

conclusionThis study provides a systematic multi-omics characterization of immune microenvironment remodelling in CRC and identifies candidate molecular regulators that may serve as potential targets for future immunotherapy research.

Indexed as

Colorectal NeoplasmsProteomicsTumor MicroenvironmentGene Expression Regulation, NeoplasticGenomicsHumansMultiomicscolorectal cancerdrug targetsImmune microenvironmentmulti-omicsphosphoproteome

Identifiers

PMID42674818
PMCPMC13531126

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.