ArticleCellular and molecular gastroenterology and hepatology2026
Sirtuin 2 Contributes to Pancreatic Injury and Inflammation by Modulating Immediate Early Response 3-Mediated Ferroptosis in Acute Pancreatitis.
Article in Cellular and molecular gastroenterology and hepatology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
BACKGROUND &
aimsAcute pancreatitis is a potentially life-threatening inflammatory disorder characterized by trypsin overactivation within acinar cells. Although sirtuin 2 is linked to inflammation, its precise role in acute pancreatitis remains poorly understood.
methodsRats were pretreated with AGK2 a (sirtuin 2 inhibitor), Ferrostatin-1 (ferroptosis inhibitor), 1α,25-dihydroxyvitamin D3 (an immediate early response 3 inhibitor), adeno-associated virus-sirtuin 2, or adeno-associated virus-short hairpin-sirtuin 2 before L-arginine-induced acute pancreatitis. RNA sequencing was performed to identify potential downstream targets of sirtuin 2. In vitro, sirtuin 2 and immediate early response 3 expression was manipulated by small interfering RNA or overexpression plasmids. The effects on ferroptosis and inflammation were assessed using Western blot, quantitative polymerase chain reaction, immunofluorescence, and assays measuring reactive oxygen species, iron (II), mitochondrial membrane potential, and lipid peroxidation. Regulatory mechanisms among sirtuin 2, immediate early response 3, and ferroptosis were further investigated using co-immunoprecipitation and dual-luciferase assays.
resultsAGK2 or ferrostatin-1 alone reduced pancreatic damage, inflammation, and ferroptosis, with combination therapy showing synergy. Sirtuin 2 or immediate early response 3 inhibition was protective, upregulating solute carrier family 7 member 11-glutathione peroxidase 4, reducing reactive oxygen species, iron (II), and lipid peroxides, and restoring mitochondrial function. Conversely, overexpression of sirtuin 2 or immediate early response 3 produced the opposite effects. AGK2 and 1α,25-dihydroxyvitamin D3 reversed damage from sirtuin 2 overexpression. Co-immunoprecipitation confirmed sirtuin 2 deacetylates and upregulates immediate early response 3. Luciferase assays showed immediate early response 3 transcriptionally represses solute carrier family 7 member 11. Clinically, serum sirtuin 2 and immediate early response 3 were elevated in patients with acute pancreatitis and correlated with disease severity and inflammation.
conclusionsSirtuin 2 enhances immediate early response 3 expression via deacetylation, inhibiting the solute carrier family 7 member 11-glutathione peroxidase 4 axis and promoting ferroptosis, thereby exacerbating acute pancreatitis. Serum sirtuin 2 and immediate early response 3 are potential biomarkers for acute pancreatitis severity. This study reveals a novel sirtuin 2-immediate early response 3-mediated mechanism driving ferroptosis in acute pancreatitis.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.