Evidence map›Paper›PMID 42673281›Full record

ArticleChemistry & biodiversity2026

Phytochemical Characterization of Extracts From Aesculus hippocastanum L. Seeds and Quantification of Saponins Using HPLC-DAD and a Novel Tensiometric Approach.

Khadijeh Nosrati Gazafroudi, Rieka Dreher, Morwen Liebscher, Peter Lorenz, Rolf Daniels, Florian C Stintzing, Dietmar R Kammerer

Abstract read
In one paragraph

Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Khadijeh Nosrati GazafroudiDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.ORCID https://orcid.org/0009-0005-3214-7271
Rieka DreherDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.
Morwen LiebscherDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.
Peter LorenzDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.ORCID https://orcid.org/0000-0001-8664-0911
Rolf DanielsDepartment of Pharmaceutical Technology, University of Tübingen, Tübingen, Germany.
Florian C StintzingDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.
Dietmar R KammererDepartment of Analytical Development and Research, Section Phytochemical Research, WALA Heilmittel GmbH, Eckwälden, Germany.ORCID https://orcid.org/0000-0003-1126-3431

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Aesculus hippocastanum L. is a well-established medicinal plant used for the treatment of venous disorders and inflammation. Despite its wide therapeutic application, systematic comparisons of the phytochemical profile of horse chestnut seed extracts prepared according to pharmacopeial extraction protocols remain scarce. Consequently, this study aimed to characterize and compare the metabolite profiles of hydroalcoholic and aqueous fermented seed extracts prepared according to official pharmacopeial procedures. Extracts were analyzed using high-performance liquid chromatography coupled to diode array and electrospray ion-trap mass spectrometric detection (HPLC-DAD-ESI-MS

Indexed as

AesculusPhytochemicalsPlant ExtractsSaponinsSeedsChromatography, High Pressure LiquidGas Chromatography-Mass SpectrometrySpectrometry, Mass, Electrospray IonizationPhytochemicalsPlant ExtractsSaponinsextractsgas chromatographyhorse chestnutHPLC‐DAD‐MSnatural productssecondary metabolitestensiometry

Identifiers

PMID42673281
PMCPMC13529266

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.