ArticleChemistry & biodiversity2026
Pharmacokinetics and Tissue Distribution in Rats After Oral Administration of Tibetan Medicine Wuwei Leze Powder.
Article in Chemistry & biodiversity, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Wuwei Leze Powder (WLP, སླྱེ་ཏྱེསལྔ་ཐང།) is a classic Tibetan medicine formula with clinical efficacy against rheumatoid arthritis (RA), but its in vivo pharmacokinetic (PK) behavior is unclear. This study aimed to elucidate the absorption, metabolism, pharmacokinetics, and tissue distribution of WLP in rats. UPLC-Q-TOF-MS and UPLC-QQQ-MS were used to qualitatively and quantitatively analyze WLP components in rat plasma and tissues. Fifty-six plasma constituents (21 prototypes, 35 metabolites) were identified. Nine compounds-syringin, cordifolioside A, sweroside, mangiferin, norswertianolin, isovitexin, ellagic acid, amarogentin, and arjungenin-were quantified. All were detectable in plasma within 15 min, with peak concentrations at 0.75-2 h ellagic acid and mangiferin showed the highest systemic exposure (AUC
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