Evidence map›Paper›PMID 42672047›Full record

ArticleClinical transplantation2026

Real-World Use of Normothermic Machine Perfusion in Liver Transplantation: A Multi-Institutional Experience From the National Organ Perfusion Registry.

Alexander R Cortez, Wei San Loh, Sarah Sheskey, Hillary J Braun, Aashna Mehta, Christopher Connelly, Austin Schenk, Musab Alebrahim, Raj Patel, Lori A McLamb and 4 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Clinical transplantation, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors.

Alexander R CortezDivision of Transplant Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Wei San LohSection of Transplant Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Sarah SheskeySection of Transplant Surgery, University of Michigan, Ann Arbor, Michigan, USA.
Hillary J BraunDepartment of Surgery, Division of Transplant, University of California San Francisco, San Francisco, California, USA.
Aashna MehtaDivision of Transplant Surgery, Mayo Clinic, Rochester, Minnesota, USA.
Christopher ConnellyDepartment of Surgery, Oregon Health & Science University, Portland, Oregon, USA.
Austin SchenkDepartment of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Musab AlebrahimDepartment of Surgery, Ohio State University Wexner Medical Center, Columbus, Ohio, USA.
Raj PatelDepartment of Surgery, University of Arkansas for Medical Sciences, Little Rock, Arkansas, USA.
Lori A McLambDepartment of Surgery, Duke University Hospital, Durham, North Carolina, USA.
Andrew BarbasDepartment of Surgery, Duke University Hospital, Durham, North Carolina, USA.
Steven A WiselComprehensive Transplant Center, Cedars-Sinai Medical Center, Los Angeles, California, USA.
Garrett R RollDepartment of Surgery, Division of Transplant, University of California San Francisco, San Francisco, California, USA.
Kyle H SheetzSection of Transplant Surgery, University of Michigan, Ann Arbor, Michigan, USA.

Funding

JoAnn Busuttil Surgeon Scientist
6 · The paper itself

Abstract

Normothermic machine perfusion (NMP) has enabled increased utilization of high-risk liver allografts; however, real-world data describing use, perfusion logistics, and associated outcomes remain limited. We established the National Organ Perfusion Registry (NOPR), a multicenter collaborative registry designed to capture granular perfusion data not available in the national transplant datasets. Adult liver transplant recipients who underwent transplantation using NMP between 2022 and 2024 at nine U.S. centers were included. Registry data were linked to the United Network for Organ Sharing (UNOS) Standard Transplant Analysis and Research files to obtain donor and recipient characteristics and post-transplant outcomes. Descriptive analyzes were performed to characterize the indications for NMP use, procurement practices, perfusion timing parameters, and early graft outcomes. A total of 545 NMP liver transplants were analyzed, including 282 donations after circulatory death (DCD) and 263 donations after brain death (DBD). DCD was the most common indication for NMP, and its incidence increased substantially during the study period. Perfusion practices varied, including procurement strategy, device use, time from cross-clamp to NMP initiation, and total perfusion duration. Despite this heterogeneity, early outcomes were favorable, with a 90-day death-censored graft failure rate of 1.7%, and no difference between DCD and DBD grafts. Recipients of DCD grafts had a shorter post-transplant length of stay than DBD recipients. In this multicenter, real-world cohort analysis, NMP was associated with low rates of early graft failure across diverse centers and perfusion practices. These findings support the feasibility of contemporary NMP use and underscore the importance of continued multicenter evaluation to refine perfusion strategies.

Indexed as

Graft RejectionLiver TransplantationOrgan PreservationPerfusionRegistriesTissue and Organ ProcurementTissue DonorsAdultFemaleFollow-Up StudiesGraft SurvivalHumansMaleMiddle AgedPrognosisRisk Factorsdonation after cardiac deathliver transplantationmachine perfusionnormothermic perfusion

Identifiers

PMID42672047
PMCPMC13528972

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.