Evidence map›Paper›PMID 42671683›Full record

ArticleEsophagus : official journal of the Japan Esophageal Society2026

Factors associated with marked reduction in tongue pressure in patients with esophageal cancer during neoadjuvant chemotherapy.

Takuya Fukushima, Makoto Yamasaki, Nobuyuki Yamamoto, Yasuaki Arima, Taisei Ashida, Shuta Takaishi, Hanako Koda, Satoshi Toshiyama, Takashi Harino, Yuki Hashimoto and 5 more

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Article in Esophagus : official journal of the Japan Esophageal Society, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

15 authors.

Takuya FukushimaFaculty of Rehabilitation, Kansai Medical University, 18-89 Uyamahigashicho, Hirakata, Osaka, 573-1136, Japan. fukushima.tky@kmu.ac.jp.
Makoto YamasakiDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Nobuyuki YamamotoDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Yasuaki ArimaDepartment of Rehabilitation, Kansai Medical University Hospital, Osaka, Japan.
Taisei AshidaDepartment of Rehabilitation, Kansai Medical University Hospital, Osaka, Japan.
Shuta TakaishiDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Hanako KodaDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Satoshi ToshiyamaDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Takashi HarinoDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Yuki HashimotoDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Masaya KotsukaDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Takuji SatoDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Kentaro InoueDepartment of Upper Gastrointestinal Surgery, Kansai Medical University, Osaka, Japan.
Kimitaka HaseDepartment of Physical Medicine & Rehabilitation, Kansai Medical University, Osaka, Japan.
Jiro NakanoFaculty of Rehabilitation, Kansai Medical University, 18-89 Uyamahigashicho, Hirakata, Osaka, 573-1136, Japan.

Funding

JSPS KAKENHI 25K00126
6 · The paper itself

Abstract

backgroundTongue pressure is a predictor of postoperative aspiration. This study aimed to examine changes in tongue pressure during neoadjuvant chemotherapy (NAC), identify associated factors, and investigate whether these changes are related to other functional outcomes, including exercise capacity and muscle function.

methodsThis prospective, single-center, observational study enrolled 68 patients with esophageal cancer scheduled to undergo NAC. Patients were classified into marked reduction (n=17) and remaining (n=51) groups based on the rate of change in tongue pressure. Tongue pressure, muscle function, walking ability, and exercise capacity were evaluated before and after NAC. Multivariate logistic regression analysis was performed to identify the factors significantly associated with a marked reduction in tongue pressure. Spearman's correlation analysis was used to evaluate the relationships between the rate of change in tongue pressure and the rates of change in each functional parameter.

resultsMultivariable logistic regression analysis identified age and the number of days during NAC when oral intake was not possible as significant independent factors associated with a marked reduction in tongue pressure. Spearman's correlation analysis revealed no significant correlations between the rate of change in tongue pressure during NAC and the rates of change in handgrip strength, isometric knee extensor strength, 30-s chair stand test performance, quadriceps thickness, maximum inspiratory pressure, maximum expiratory pressure, 10-m walk test result, or 6-min walk distance.

conclusionsThese findings underscore the importance of incorporating swallowing function, including tongue pressure, into prehabilitation programs.

Indexed as

Esophageal cancerNeoadjuvant chemotherapyPrehabilitationTongue pressure

Identifiers

PMID42671683

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.