Evidence map›Paper›PMID 42671513›Full record

ArticleGeneral thoracic and cardiovascular surgery2026

Prevention of infectious complications in tracheal defects using a biodegradable polylactide patch: an experimental study.

Andrei V Nikulin, Ekaterina V Blinova, Alexandra A Fomichevа, Tatiana N Sotnikova, Polina A Kovaleva, Anna I Cheremnykh, Iliya N Sorokvasha, Ivar S Struts, Kirill D Blinov, Tatiana V Khorobrykh

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Article in General thoracic and cardiovascular surgery, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

Andrei V NikulinDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048. nikulin5642@gmail.com.ORCID http://orcid.org/0000-0001-8949-9554
Ekaterina V BlinovaDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048.
Alexandra A FomichevаDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048.
Tatiana N SotnikovaI.V. Davydovsky City Clinical Hospital, Moscow Department of Health, 11/6 Yauzskaya St, Moscow, Russian Federation, 109240.
Polina A KovalevaNational University of Science and Technology MISIS (NUST MISIS), Moscow, Russian Federation.
Anna I CheremnykhNational University of Science and Technology MISIS (NUST MISIS), Moscow, Russian Federation.
Iliya N SorokvashaNational Research Nuclear University MEPhI, 31, Kashirskoe shosse, Moscow, Russian Federation, 115409.
Ivar S StrutsDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048.
Kirill D BlinovDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048.
Tatiana V KhorobrykhDepartment of Faculty Surgery No. 2, N. V. Sklifosovsky Institute of Clinical Medicine, I.M. Sechenov First Moscow State Medical University (Sechenov University), 15/2 Dovator St., Moscow, Russian Federation, 119048.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTracheal surgery is associated with substantial morbidity, and anastomotic failure can lead to life-threatening infectious complications such as mediastinitis. This study aimed to evaluate whether a biodegradable polylactide patch can close an experimental tracheal defect in mice and prevent such complications.

methodsIn 30 male BALB/c mice, a window defect was created in the anterior tracheal wall. In Group 1 (control, n = 15) the defect was closed with two interrupted sutures only. In Group 2 (experimental, n = 15) the defect was repaired using an electrospun polylactide (PLA) patch secured with two interrupted sutures. Postoperative monitoring included daily semiquantitative clinical scoring (6 parameters, 0-3 scale) in addition to survival and histological assessment on days 7, 14, and 21.

resultsAll mice in the experimental group survived with no signs of infection and clinical scores ≤ 1. In the control group, 5 of 15 mice developed cervical phlegmon (two died spontaneously, three were euthanized with purulent exudate); the other 10 mice without phlegmon survived. Histologically, the control group exhibited persistent inflammation, tissue disorganisation, and incomplete epithelial regeneration (flattened epithelium with occasional ciliated patches). The PLA patch group showed progressive polymer degradation, minimal inflammation, and complete restoration of a ciliated respiratory epithelium by day 21.

conclusionThe PLA patch prevented infectious complications and mortality, promoted full ciliated epithelialization, and demonstrated high biocompatibility, supporting its use in tracheal reconstructive surgery.

Indexed as

Biodegradable materialsExperimental studyInfectious complicationsPolylactideTracheal defects

Identifiers

PMID42671513

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.