Evidence map›Paper›PMID 42671483›Full record

ArticleTAG. Theoretical and applied genetics. Theoretische und angewandte Genetik2026

Genome wide association studies and expression analyses identify candidate genes for spot blotch resistance in bread wheat.

G Mahendra Singh, Uttam Kumar, Bhagya Shree Acharya, Pradeep Bhati, Manish Vishwakarma, Dinesh Kumar Saini, Sundeep Kumar, Vinod K Mishra, Arun K Joshi, Sandeep Sharma

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Article in TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

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4 · The record

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5 · Who and what money

Authors and funding

10 authors.

G Mahendra SinghDepartment of Genetics and Plant Breeding, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, India.ORCID http://orcid.org/0000-0003-4363-3417
Uttam KumarBorlaug Institute for South Asia (BISA), Ludhiana, Punjab, India.ORCID http://orcid.org/0000-0002-6618-3810
Bhagya Shree AcharyaDepartment of Genetics and Plant Breeding, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, India.ORCID http://orcid.org/0009-0008-8591-0658
Pradeep BhatiBorlaug Institute for South Asia (BISA), Ludhiana, Punjab, India.ORCID http://orcid.org/0000-0002-5355-6825
Manish VishwakarmaBorlaug Institute for South Asia (BISA), Ludhiana, Punjab, India.ORCID http://orcid.org/0000-0001-8068-2280
Dinesh Kumar SainiTexas Tech University, Lubbock, USA.ORCID http://orcid.org/0000-0002-6347-6183
Sundeep KumarICAR-NBPGR, New Delhi, India.ORCID http://orcid.org/0000-0002-0015-8559
Vinod K MishraDepartment of Genetics and Plant Breeding, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, India. vkmishra.gpb@bhu.ac.in.ORCID http://orcid.org/0000-0002-3068-1199
Arun K JoshiBorlaug Institute for South Asia (BISA), Ludhiana, Punjab, India.ORCID http://orcid.org/0000-0003-4205-9329
Sandeep SharmaDepartment of Genetics and Plant Breeding, Institute of Agricultural Sciences, Banaras Hindu University, Varanasi, India. sksbhu@bhu.ac.in.ORCID http://orcid.org/0000-0003-1087-6252

Funding

Department of Biotechnology, Ministry of Science and Technology, India BT/PR48017/AGMI/103/1425/2023
6 · The paper itself

Abstract

key messageGWAS of 1,273 wheat lines identified a stable MTA 3B_6127880 on 3BS chromosome arm for spot blotch resistance, and the associated candidate genes were differentially expressed in resistant vs. susceptible genotypes. Spot blotch (SB), caused by Bipolaris sorokiniana, poses a threat to global wheat production. We evaluated 1,500 elite wheat lines for SB across two environments to identify genomic regions and candidate genes (CGs) conferring resistance. Disease severity, measured as area under the disease progress curve (AUDPC), was negatively correlated with days to heading (DH) and stay-green traits (SGTs). Genome-wide association studies (GWAS) using three different models (MLM, FarmCPU, BLINK) identified seven and eleven stable MTAs for AUDPC and SGTs, respectively, with three (3B_6127880, 5B_546704556, 5B_546132836) common to both traits. To reduce the confounding effects of DH, a separate GWAS was conducted on a subset of genotypes with similar heading dates, confirming 3B_6127880 as a consistent locus for AUDPC, located near to previously known SB QTLs on 3BS chromosome arm. Several other putative MTAs and haplotypes associated with AUDPC and SGTs were identified. A time-course analysis of CGs associated with the important MTAs revealed differential expression in the resistant (Chirya 3) and susceptible (Sonalika) genotypes under SB infection. The identified SNPs, alleles, haplotypes, and CGs may be used in marker-assisted selection and breeding programs to develop wheat varieties with enhanced resistance to SB.

Indexed as

Disease ResistancePlant DiseasesTriticumAscomycotaChromosome MappingChromosomes, PlantGene Expression Regulation, PlantGenes, PlantGenetic Association StudiesGenetic MarkersGenome-Wide Association StudyGenotypePhenotypePolymorphism, Single NucleotideQuantitative Trait LociGenetic Markers

Identifiers

PMID42671483

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.