Evidence map›Paper›PMID 42671318›Full record

ArticleFASEB journal : official publication of the Federation of American Societies for Experimental Biology2026

Sesamin Promotes Diabetic Wound Healing by Inhibiting Ferroptosis via the SIRT1/Keap1/Nrf2 Pathway.

Xin Wen, Sheng-Tuo Zhou, Gao-Sheng Zhu, Tao Xu, Zi-Huai Huang, Yue-Ting Wang, Jian-Zuo Lu

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in FASEB journal : official publication of the Federation of American Societies for Experimental Biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Xin WenDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Sheng-Tuo ZhouDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Gao-Sheng ZhuDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Tao XuDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Zi-Huai HuangDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Yue-Ting WangDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.
Jian-Zuo LuDepartment of Orthopedics, The People's Hospital of Wenzhou City, Wenzhou, China.ORCID https://orcid.org/0009-0007-3660-3996

Funding

the Wenzhou Science and Technology Bureau Project Y20220925
6 · The paper itself

Abstract

Diabetes mellitus frequently leads to diabetic wounds (DW), a serious complication for which current treatment options remain limited. This work examined the pro-healing effects of sesamin (Sea), a major sesame lignan, on DW and the mechanisms underlying these effects. In vitro, human umbilical vein endothelial cells (HUVECs) were cultured under high glucose (HG) conditions to mimic diabetic dysfunction. Cell viability, lipid peroxidation, Fe

Indexed as

Diabetes Mellitus, ExperimentalDioxolesFerroptosisKelch-Like ECH-Associated Protein 1LignansNF-E2-Related Factor 2Sirtuin 1Wound HealingAnimalsHumansHuman Umbilical Vein Endothelial CellsMaleMiceMice, Inbred C57BLReactive Oxygen SpeciesSignal TransductionDioxolesKEAP1 protein, humanKeap1 protein, mouseKelch-Like ECH-Associated Protein 1LignansNFE2L2 protein, humanNfe2l2 protein, mouseNF-E2-Related Factor 2Reactive Oxygen SpeciessesaminSIRT1 protein, humanSirtuin 1diabetic woundferroptosishuman umbilical vein endothelial cellssesaminSirt1/Keap1/Nrf2 signaling pathway

Identifiers

PMID42671318
PMCPMC13528641

What OpenQuestion holds

Textmetadata
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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.