ArticleClinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis
Diagnostic Value of Hematological Inflammatory Indices (NLR, PLR, HPR) in Thrombotic Thrombocytopenic Purpura: A Case-Control Study.
Article in Clinical and applied thrombosis/hemostasis : official journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background and AimThrombotic thrombocytopenic purpura (TTP) is a life-threatening and rare thrombotic microangiopathy (TMA) described as severe thrombocytopenia, microangiopathic hemolytic anemia, and ischemic end-organ injury because of microvascular platelet-rich thrombi. Recent findings show inflammatory conditions such as infection and surgery can be triggers for TTP onset. The aim of this study was to evaluate the diagnostic performance and clinical relevance of hematological inflammatory indices (NLR, PLR, and HPR) in patients with thrombotic thrombocytopenic purpura compared with healthy controls.MethodsThis case-control study was conducted on 114 TTP patients (90 female and 24 male) and 115 healthy controls from January 2010 to December 2022 in Imam Reza Hospital, Mashhad, Iran. Immune cell counts, inflammatory parameters, and hematological markers including NLR, PLR, and HPR were calculated using the complete blood count at the time of diagnosis and after the treatment. Statistical analyses were conducted by MedCalc, IBM SPSS Statistics version 26 and GraphPad Prism version 9.5.0.ResultThe result showed that at the time of admission, systemic (70.2%), bleeding (40.4%), and renal (41.2%) symptoms were the most frequent, whereas a lower prevalence of neurological (22.8%) signs and symptoms was observed. White blood cell (WBC) and neutrophil counts were higher in TTP patients (WBC: p< 0.001, neutrophil: p<0.001), and conversely, platelet and lymphocyte counts were higher in the control group compared to TTP patients (platelets: p<0.001, lymphocytes: p<0.001). The indices analysis between the two groups revealed that NLR and HPR were significantly increased in TTP patients (p<0.001), but PLR was significantly reduced in TTP patients (with the mean platelet count of 62.09 ± 55.37× 10
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