ReviewJournal of inflammation research2026
Expression Profiles, Biological Functions and Clinical Significance of Circular RNAs in Inflammatory Bowel Disease.
Review in Journal of inflammation research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Inflammatory bowel disease (IBD) is a chronic, relapsing inflammatory condition affecting the gastrointestinal tract, primarily encompassing Crohn's disease (CD) and ulcerative colitis (UC). IBD is characterized by insidious onset, diagnostic challenges, and lack of curative therapies. Despite substantial research efforts, the precise etiology and pathogenesis of IBD remain incompletely elucidated. Furthermore, reliable biomarkers and satisfactory therapeutic strategies for clinical management of IBD patients are still lacking. Circular RNAs (circRNAs) constitute a class of non-coding RNAs characterized by covalently closed circular structures, which are abundantly expressed in eukaryotic cells. Circular RNAs are characterized by their biochemical stability, tissue specificity, and developmental stage specificity. Accumulating evidence suggests that circRNAs are implicated in the development and progression of IBD. Aberrant circRNA expression in IBD is considered a critical factor modulating intestinal immune homeostasis and barrier function through the regulation of immuno-inflammatory responses, tight junction protein expression, autophagy, apoptosis, and other pathophysiological processes. This review comprehensively examines relevant articles published in recent years, elucidating the biogenesis and functional roles of circRNAs, summarizing their biological implications and potential mechanisms in IBD, and exploring their clinical significance. We anticipate that this review will provide valuable insights into the potential of circRNAs as specific targets for the diagnosis and treatment of IBD in future research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.