ArticleVeterinary medicine international2026
Circulating pTau181 and Genomic Background in Dogs: A Pilot Study on Neurobiological Aging.
Article in Veterinary medicine international, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
1 citing paper in PubMed.
- Circulating pTau181 and Genomic Background in Dogs: A Pilot Study on Neurobiological Aging.Veterinary medicine international · 2026Article
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Aging in dogs mirrors key biological aspects of human aging, including molecular processes associated with neurodegeneration, making the dog a valuable comparative model. This pilot study investigated the integration of circulating blood biomarkers and genomic architecture to explore interindividual variability associated with neurobiological aging in dogs. Forty-eight dogs (31 purebred Labrador Retrievers and 17 mixed-breed dogs; age range: 2-15 years) were analyzed for serum phosphorylated tau at threonine 181 (pTau181). Genome-wide SNP genotyping was performed to characterize population structure, estimate pedigree- and ROH-based genomic inbreeding, and conduct an exploratory genome-wide association study (GWAS). Circulating pTau181 produced a quantifiable signal, but a subset of values fell below the assay's lower limit of detection and were coded as zero for statistical analysis. Data showed a continuous distribution, with mean values ranging from 6.1 to 13.4 pg/mL across demographic groups. No significant associations were observed between pTau181 concentrations and age category, sex, or breed group. Genomic analyses revealed clear population stratification between Labrador Retrievers and mixed-breed dogs, with significantly higher genomic homozygosity in Labradors (FROH = 0.26 ± 0.05) compared with mixed breeds (FROH = 0.12 ± 0.14;
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Registered trials
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