ArticleDrug design, development and therapy2026
Establishing the Median Effective Dose of Tegileridine for Immediate Postoperative Analgesia Following Laparoscopic Colorectal Cancer Surgery: A Sequential Dose-Finding Study.
Article in Drug design, development and therapy, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Abstract
Background: To determine the median effective dose (ED Methods: A modified Dixon's up-and-down sequential method was employed, starting with an initial tegileridine dose of 15 µg/kg and a dose ratio of 1:1.1. Patients undergoing elective LCRS received a standardized multimodal analgesic background, including a transversus abdominis plane block and intraoperative sufentanil, and received intravenous tegileridine 10 minutes before the end of surgery. A blinded investigator assessed pain using the Numerical Rating Scale (NRS) at 15 and 30 minutes, and 2 hours post-extubation. Effective analgesia was defined as an NRS score ≤ 3 without rescue analgesia within 2 hours. The ED Results: Analysis of the 40 patients revealed that the ED Conclusion: This exploratory study provides a preliminary ED
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