Evidence map›Paper›PMID 42670086›Full record

ArticleJournal of immunology research2026

P2Y

Abdoul Karim Ouattara, Fariborz Bahrami, Radu Adrian Turcitu, Filip Kukulski, Joanna Lecka, Julie Pelletier, Nicolly Espindola Gelsleichter, Tais Vidal, Jean Sévigny

Abstract read
In one paragraph

Article in Journal of immunology research, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors.

Abdoul Karim OuattaraDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.ORCID https://orcid.org/0000-0002-9767-0646
Fariborz BahramiDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.ORCID https://orcid.org/0000-0001-9561-415X
Radu Adrian TurcituDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.ORCID https://orcid.org/0000-0001-7651-6853
Filip KukulskiDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.
Joanna LeckaDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.
Julie PelletierAxe Maladies Infectieuses et Immunitaires, Centre de Recherche du CHU de Québec - Université Laval, Québec City G1V 4G2, Quebec, Canada, ulaval.ca.
Nicolly Espindola GelsleichterDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.ORCID https://orcid.org/0000-0002-8342-3281
Tais VidalDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.
Jean SévignyDépartement de Microbiologie-Infectiologie et d'immunologie, Centres PROTEO et ARThrite, Faculté de Médecine, Université Laval, Québec City G1V 0A6, Quebec, Canada, ulaval.ca.ORCID https://orcid.org/0000-0003-2922-1600

Funding

CIHR MOP-93683CIHR PJT - 156205Fonds de recherche du Québec 30641
6 · The paper itself

Abstract

Toll-like receptors (TLRs) and P2 receptors are key regulators of innate immunity. During infection, pathogen-associated molecular patterns (PAMPs) activate TLRs, whereas extracellular nucleotides engage P2 receptors and influence inflammatory responses. Here, we show that polyinosinic:polycytidylic acid (poly[I:C])-activated TLR3 and P2Y

Indexed as

ChemokinesEpithelial CellsIntestinal MucosaReceptors, Purinergic P2Y2Toll-Like Receptor 3AnimalsHT29 CellsHumansInnate Immunity RecognitionInterleukin-8MiceMice, KnockoutPoly I-CSignal TransductionToll-Like Receptor AgonistsChemokinesInterleukin-8Poly I-CReceptors, Purinergic P2Y2TLR3 protein, humanToll-Like Receptor 3Toll-Like Receptor AgonistsCXCL10/IP-10CXCL8/IL-8intestinal epithelial cellsP2RY2TLR3

Identifiers

PMID42670086
PMCPMC13527233

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.