Evidence map›Paper›PMID 42669856›Full record

ArticleVeterinary ophthalmology2026

Spontaneous Superficial Ulcerative Keratitis in Client-Owned Cats: Risk Factors for Delayed Healing, Corneal Sequestration, or Corneal Stromal Vascularization.

Benjamin D Reynolds, Cameron J Whittaker, Kelly A Caruso, Jeffrey S Smith, William Weinstein, Paul G McCarthy, William M Irving, David J Maggs

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Veterinary ophthalmology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0citing papers in PubMed
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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Benjamin D ReynoldsLas Vegas Veterinary Specialty Center, Las Vegas, Nevada, USA.ORCID https://orcid.org/0000-0002-2306-8054
Cameron J WhittakerEye Clinic for Animals, Artarmon, New South Wales, Australia.ORCID https://orcid.org/0009-0003-4693-6373
Kelly A CarusoEye Clinic for Animals, Artarmon, New South Wales, Australia.ORCID https://orcid.org/0000-0001-6139-4486
Jeffrey S SmithEye Clinic for Animals, Artarmon, New South Wales, Australia.
William WeinsteinLas Vegas Veterinary Specialty Center, Las Vegas, Nevada, USA.
Paul G McCarthyEye Clinic for Animals, Artarmon, New South Wales, Australia.ORCID https://orcid.org/0000-0003-2261-1016
William M IrvingEye Clinic for Animals, Artarmon, New South Wales, Australia.
David J MaggsDepartment of Surgical and Radiological Sciences, School of Veterinary Medicine, University of California-Davis, Davis, California, USA.ORCID https://orcid.org/0000-0001-6537-4335

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeTo investigate risk factors for delayed healing, corneal sequestration, or corneal stromal vascularization in cases of spontaneous superficial feline ulcerative keratitis.

methodsA retrospective review was performed of 71 corneal ulcers in 68 cats. Patient factors, medications, treatments and time until first recheck were each assessed to determine relationships with delayed ulcer healing (> 1 SD above mean healing time), corneal sequestration, or corneal stromal vascularization after ulcer healing.

resultsDelayed healing (8/71; 11.3%), corneal sequestration (20/71; 28.2%) and corneal stromal vascularization after ulcer healing (9/71; 12.7%) occurred commonly. Corneal ulcers were significantly more likely to experience delayed healing if chemosis was initially present (p = 0.04), or if therapy included oral lysine (p = 0.04), topical nonsteroidal anti-inflammatory drugs (NSAIDS; p = 0.03) or topical ethylenediaminetetraacetic acid (EDTA; p = 0.04). Ulcerated corneas were significantly more likely to undergo sequestration following cotton-tipped applicator (CTA) debridement (OR = 4.1, p = 0.03), or if faint corneal brunescence was initially present (OR = 5.0, p = 0.01). Corneal stromal vascularization after ulcer healing was significantly more likely in Persian cats (OR = 7.3, p = 0.02) or if corneal vascularization was initially present (OR = 8.6, p = 0.01).

conclusionsDelayed healing, corneal sequestration, and corneal stromal vascularization appear to be common sequelae of feline ulcerative keratitis. Clinicians should use caution when treating feline ulcers using oral lysine, topical NSAIDs, topical EDTA, or CTA debridement.

Indexed as

Cat DiseasesCorneal NeovascularizationCorneal UlcerAnimalsAnti-Inflammatory Agents, Non-SteroidalCatsCorneal StromaFemaleMaleRetrospective StudiesRisk FactorsWound HealingAnti-Inflammatory Agents, Non-Steroidalcorneal debridementdendritic ulcerlysinePersiansequestrumulcerative keratitis

Identifiers

PMID42669856
PMCPMC13527177

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.