Evidence map›Paper›PMID 42669768›Full record

ArticleNeuroscience bulletin2026

PTPRO Governs Synaptic Density, Long-Term Potentiation and Cognitive Function In Vivo.

Xiangdong Wang, Jiaguo Wu, Mengna Liu, Kun Zhang, Xinping Yuan, Fangting Xing, Wenjie Xu, Yulin Zheng, Yifei Wu, Lin Luo and 5 more

Abstract read
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In one paragraph

Article in Neuroscience bulletin, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Xiangdong Wang *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Jiaguo Wu *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Mengna Liu *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Kun Zhang *State Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China.
Xinping Yuan *School of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Fangting XingSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Wenjie XuSchool of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, 325035, China.
Yulin ZhengSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Yifei WuSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Lin LuoSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Xinyi DingSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Ge GaoSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China.
Mengping WeiSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. weimengping@ccmu.edu.cn.
Jing LiangState Key Laboratory of Cognitive Science and Mental Health, Institute of Psychology, Chinese Academy of Sciences, Beijing, 100101, China. liangj@psych.ac.cn.
Chen ZhangSchool of Basic Medical Sciences, Capital Medical University, Beijing, 100069, China. czhang@ccmu.edu.cn.ORCID https://orcid.org/0000-0002-7940-8054

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Protein Tyrosine Phosphatase Receptor Type O (PTPRO) is a synaptic cell adhesion molecule that is essential for synapse formation in vitro; however, its in vivo role remains unclear. Using PTPRO-knockout mice, we found that PTPRO deletion reduced the number of synapses and impaired both excitatory and inhibitory synaptic transmission. PTPRO knockout also disrupted hippocampal long-term potentiation and caused learning and memory deficits in the water maze as well as in fear conditioning. Notably, overexpression of the N-terminal extracellular domain of PTPRO rescued the frequencies of miniature excitatory postsynaptic currents and inhibitory postsynaptic currents, indicating that this domain is required to regulate synapse number and transmission. Collectively, these data demonstrate that PTPRO is essential for maintaining synapse number, synaptic transmission, long-term potentiation, and learning and memory functions in vivo.

Indexed as

Learning and memoryLong-term potentiationPTPROSynapse formationSynaptic transmission

Identifiers

PMID42669768

What OpenQuestion holds

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.