ArticleNeurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology2026
Unawareness of motor deficit in Huntington's disease.
Article in Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
introductionUnawareness of chorea is well-known in Huntington's disease (HD). This study investigated unawareness for the whole gamut of motor impairments in daily life, which has not been explored previously.
methodsData from 71 consecutive patients with stage I or II HD were assessed retrospectively. The motor section of UHDRS; the total functional capacity; a short battery of cognitive tests; the SANS and SAPS scales for negative and positive psychiatric symptoms; the Hamilton scales for depression (HAM-D) and anxiety (HAM-A); and a semi-structured questionnaire to assign motor anosognosia on a scale from 0 (fully aware) to 3 (severely unaware), were administered.
resultsTwenty-seven (38%) patients were aware of their motor symptoms, and 44 (62%) were unaware: 29/44 (66%) score 1, 11 (25%) score 2, and 4 (9%) score 3. When their motor deficits were pointed out, the severely unaware patients insisted on having no impairments contrary to all evidence. Unaware patients performed worse on the visual search test (p = 0.04) and SANS (apathy) (p = 0.02) than aware patients. Comparison between the three groups defined by anosognosia scores 0, 1, and 2 + 3, showed that SANS (p = 0.04) and HAM-A (p = 0.036) differed significantly between the groups, with apathy increasing and anxiety reducing with worsening anosognosia. Furthermore, anosognosia score correlated directly with apathy (Spearman's rho = 0.311; p = 0.008) and indirectly with anxiety (rho= -0.288; p = 0.015), visual search (rho= -0.247; p = 0.038), and verbal fluency (rho= -0.243; p = 0.041).
conclusionsAnosognosia in HD appears multifactorial: executive impairment, apathetic syndrome, and perhaps delusional ideation may contribute to its occurrence and severity.
Indexed as
Identifiers
42669758What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.