Evidence map›Paper›PMID 42669716›Full record

ArticleNature communications2026

A pathogenic CD8⁺ T

Xinyue Du, Jiashun Li, Xin Wang, Wenyu Wu, Tingjun Zhu, Huibo Yan, Chenyun Wu, Yuanyuan Li, Yuwei Gao, Haibo Yi and 10 more

Abstract read
In one paragraph

Article in Nature communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed.

  1. A pathogenic CD8⁺ TNature communications · 2026
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Xinyue Du *Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0003-3473-6027
Jiashun Li *Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0009-3769-9031
Xin Wang *Shanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0008-8703-6941
Wenyu WuSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0005-6807-4932
Tingjun ZhuNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China.
Huibo YanShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0008-4682-0473
Chenyun WuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7468-9360
Yuanyuan LiShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0009-9045-3356
Yuwei GaoShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0007-3221-9495
Haibo YiShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0009-0009-1784-9282
Kokouvi KassegneSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-7067-177X
Xiangwei LiSchool of Global Health, Chinese Center for Tropical Diseases Research, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0002-9450-7771
Xiaoyin NiuShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-9350-0300
Helena HelmbyDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0003-0761-7348
Samuel C WassmerDepartment of Infection Biology, London School of Hygiene & Tropical Medicine, London, UK.ORCID 0000-0002-6753-3376
Youqiong YeShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China.ORCID 0000-0001-8332-4710
Banchob SripaTropical Disease Research Center, Department of Tropical Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen, Thailand.
Guangjie ChenShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. guangjie_chen@163.com.ORCID 0000-0002-5446-6784
Menbao QianNational Institute of Parasitic Diseases, Chinese Center for Disease Control and Prevention (Chinese Center for Tropical Diseases Research), NHC Key Laboratory of Parasite and Vector Biology, WHO Collaborating Center for Tropical Diseases, National Center for International Research on Tropical Diseases, Shanghai, China. qianmb@nipd.chinacdc.cn.ORCID 0000-0002-3027-2889
Zhaojun WangShanghai Institute of Immunology, Department of Immunology and Microbiology, Shanghai Jiao Tong University School of Medicine, Shanghai, China. zjwang@sjtu.edu.cn.ORCID 0000-0003-2853-1850

Funding

National Natural Science Foundation of China (National Science Foundation of China) 32470957National Natural Science Foundation of China (National Science Foundation of China) 82402049Shanghai Municipal Health Bureau (Shanghai Municipal Public Health Bureau) 2024QN083
6 · The paper itself

Abstract

Chronic liver fluke infections represent a major global health burden, driving liver fibrosis and elevating cancer risk, yet the immunological mechanisms linking persistent infection to tissue damage remain poorly defined. Using Clonorchis sinensis, a carcinogenic liver fluke infecting millions worldwide, as a representative model, we map immune responses during chronic infection in mice. We show that intrahepatic CD8⁺ tissue-resident memory T cells (T

Indexed as

CD8-Positive T-LymphocytesChemokine CCL4ChemokinesClonorchiasisClonorchis sinensisLiver CirrhosisAnimalsBiomarkersChronic DiseaseFemaleHumansImmunologic MemoryLiverMaleMiceMice, Inbred C57BLBiomarkersChemokine CCL4Chemokines

Identifiers

PMID42669716
PMCPMC13526845

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.