Evidence map›Paper›PMID 42669632›Full record

ArticleAlzheimer's & dementia : the journal of the Alzheimer's Association2026

Perinatal lead (Pb) exposure and alterations to amyloid beta and metabolic profiles in the brain.

Rachel K Morgan, Evelyn K Matei, Junru Pan, Tomoko Ishikawa, Katelyn M Polemi, Ingrid Bergin, Sean P Ferris, Hao Wang, Dana C Dolinoy, Kelly M Bakulski and 1 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Alzheimer's & dementia : the journal of the Alzheimer's Association, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Rachel K MorganDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.ORCID https://orcid.org/0000-0002-0157-7755
Evelyn K MateiDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Junru PanDepartment of Nutritional Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Tomoko IshikawaDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Katelyn M PolemiDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Ingrid BerginDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Sean P FerrisSchool of Medicine, University of Michigan, Ann Arbor, Michigan, USA.
Hao WangDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Dana C DolinoyDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Kelly M BakulskiDepartment of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.
Justin A ColacinoDepartment of Environmental Health Sciences, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA.

Funding

Research Education ComponentP30AG072931 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Henry L Paulson · 2021 to 2026
$26.5M
Strategic Vision & Impact on Environmental HealthP30ES017885 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2011 to 2026
$21.3M
Environmental Epigenomics and Precision Environmental HealthR35ES031686 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Dana Dolinoy · 2020 to 2026
$6.1M
The impact of metals and polygenic risk on multiomics, brain aging, and ADRD outcomesU01AG088407 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Bakulski, Justin Adam Colacino · 2024 to 2026
$4.4M
Risk of Alzheimer's Disease and Related Dementias from Perinatal Lead Exposure: Brain Region and Cell Type EffectsR01AG072396 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Kelly Bakulski, Justin Adam Colacino · 2022 to 2026
$3.7M
The Study of the Environment and Alzheimer's disease and related Dementias (SEAD)R01AG070897 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BAKULSKI, KELLY, PARK, SUNG KYUN · 2021 to 2025
$3.4M
Understanding the role of the gut-brain axis in modulating Cadmium neurotoxicityR00ES034068 · NIEHS · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI Hao Wang · 2024 to 2026
$676k
NIA NIH HHS P30 AG072931NIA NIH HHS R01 AG070897NIA NIH HHS R01 AG072396NIA NIH HHS U01 AG088407NIEHS NIH HHS P30 ES017885NIEHS NIH HHS R00 ES034068NIEHS NIH HHS R35 ES031686NIH HHS P30AG072931NIH HHS P30ES017885NIH HHS R00ES034068NIH HHS R01AG070897NIH HHS R01AG072396NIH HHS R35ES031686NIH HHS U01AG088407
6 · The paper itself

Abstract

introductionDevelopmental neurotoxicant exposures (e.g., lead [Pb]) are suspected contributors to dementia. Dementia is characterized by amyloid beta (Aβ) plaques and dysregulated metabolism. To better understand the relationship between environment and dementia risk, we assessed the impact of perinatal Pb exposure on dementia-related outcomes in the murine brain.

methodsFemale mice were exposed to 32 ppm Pb or control water during gestation and lactation. Offspring were aged out to 3 weeks or 18 months. We measured Aβ in the 18-month cortex and performed untargeted metabolomics in plasma and cortex at 3 weeks and 18 months of age.

resultsDiffuse Aβ and Aβ-positive cells were significantly elevated with Pb exposure. Pb-associated metabolites were enriched for those implicated in oxidative stress, inflammation, and lipid metabolism. DISCUSSION: Pb was associated with molecular and metabolic features of dementia. Important biochemical classes provide insights into possible mechanisms by which developmental Pb exposure may contribute to dementia risk.

Indexed as

Amyloid beta-PeptidesBrainLeadMetabolomePrenatal Exposure Delayed EffectsAnimalsFemaleMiceOxidative StressPregnancyAmyloid beta-PeptidesLeadamyloidleadmetabolomicsneurodegenerationneurotoxicologypathology

Identifiers

PMID42669632
PMCPMC13526643

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.