ArticleInternational urology and nephrology2026
Prognostic factors for mortality and recurrence after radical nephroureterectomy for UTUC: a Brazilian cohort study.
Article in International urology and nephrology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
purposeTo evaluate the risk factors associated with mortality and recurrence following nephroureterectomy for upper tract urothelial carcinoma (UTUC) in a large Brazilian cohort.
methodsThis retrospective study analyzed 126 patients who underwent nephroureterectomy for UTUC between 2009 and 2023 at a single institution in Brazil. Cox regression and Kaplan-Meier analyses were performed to identify factors associated with mortality and recurrence.
resultsThe median follow-up duration was 38 months. In multivariate analysis, positive surgical margins (HR 3.45, 95% CI 1.52-7.69, p=0.003), presence of carcinoma in situ (HR 2.63, 95% CI 1.27-5.56, p=0.009), and systemic recurrence (HR 3.33, 95% CI 1.32-9.09, p=0.01) were independently associated with increased mortality. The laparoscopic approach was not associated with worse outcomes than open surgery.
conclusionThis large Brazilian cohort study identified several prognostic factors for mortality and recurrence after nephroureterectomy in patients with UTUC. Achieving negative surgical margins and identifying high-risk pathological features are critical for optimizing the outcomes. The laparoscopic approach was not associated with worse oncological outcomes in this cohort. These findings may help guide patient management and follow-up strategies.
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