Evidence map›Paper›PMID 42669066›Full record

ArticleAging cell2026

Higher Frontal Cortex Angiotensin Type 2 Receptor-Interacting Protein (ATIP) Levels Are Associated With a Lower Amyloid-Beta Burden in Postmortem Brains of Older Adults With Alzheimer's Disease.

Caglar Cosarderelioglu, Simion Kreimer, Alma I Plaza-Rodriguez, Pablo A Iglesias, C Conover Talbot, Helmy M Siragy, Ceereena Ubaida-Mohien, Francine Grodstein, Luigi Ferrucci, David A Bennett and 2 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Aging cell, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Caglar CosardereliogluDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-7560-1287
Simion KreimerThe Mass Spectrometry and Proteomics Facility, The Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0001-6627-3771
Alma I Plaza-RodriguezKrieger School of Arts and Sciences, Johns Hopkins University, Baltimore, Maryland, USA.
Pablo A IglesiasDepartment of Electrical and Computer Engineering, Whiting School of Engineering, Johns Hopkins University, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-0840-155X
C Conover TalbotInstitute for Basic Biomedical Sciences, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-3758-2425
Helmy M SiragyDepartment of Medicine, Division of Endocrinology and Metabolism, University of Virginia, Charlottesville, Virginia, USA.ORCID https://orcid.org/0000-0001-8121-9052
Ceereena Ubaida-MohienNational Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-4301-4758
Francine GrodsteinRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0002-2699-7051
Luigi FerrucciNational Institute on Aging, National Institutes of Health, Baltimore, Maryland, USA.
David A BennettRush Alzheimer's Disease Center, Rush University Medical Center, Chicago, Illinois, USA.ORCID https://orcid.org/0000-0003-3689-554X
Jeremy WalstonDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.
Peter AbadirDivision of Geriatric Medicine and Gerontology, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA.ORCID https://orcid.org/0000-0002-8186-0066

Funding

Technological Assessment and Solutions Core - RC4P30AG021334 · NIA · JOHNS HOPKINS UNIVERSITY · PI Jeremy D Walston · 2003 to 2026
$33.2M
Age Related Change in Mitochondrial Angiotensin System and Mitochondrial DeclineR01AG046441 · NIA · JOHNS HOPKINS UNIVERSITY · PI ABADIR, PETER M. · 2014 to 2018
$2.3M
AI-Driven Frailty Assessment and Molecular Correlation: A Multimodal Mentorship InitiativeK24AG088484 · NIA · JOHNS HOPKINS UNIVERSITY · PI Peter M. Abadir · 2024 to 2026
$596k
Bright Focus Foundation Research AwardNathan W. and Margaret T. Shock Aging Research Foundation, Nathan Shock Scholar in AgingNational Institute on Aging of the National Institutes of Health (NIH) P30AG021334NIA NIH HHS K24 AG088484NIA NIH HHS K24AG088484NIA NIH HHS P30 AG021334NIA NIH HHS R01 AG046441NIH R01AG046441
6 · The paper itself

Abstract

Alzheimer's disease (AD) is a complex neurodegenerative disorder characterized by amyloid-β (Aβ) and tau accumulation. Dysregulation of the brain renin-angiotensin system, particularly hyperactivation of the angiotensin II type-1 receptor, contributes to AD pathogenesis. In contrast, activation of the angiotensin II type-2 receptor (AT

Indexed as

Alzheimer DiseaseAmyloid beta-PeptidesBrainFrontal LobeAgedAged, 80 and overAutopsyFemaleHumansMaleReceptor, Angiotensin, Type 2Amyloid beta-PeptidesReceptor, Angiotensin, Type 2Alzheimer's diseaseangiotensinangiotensin receptor blockerAT2R‐binding protein (ATBP)AT2R‐interacting protein (ATIP)TOMAHAQ

Identifiers

PMID42669066
PMCPMC13526323

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.