Trial reportAnnals of medicine2026
Prognostic significance of systemic immunoinflammatory biomarkers and pathological features in clear cell renal cell carcinoma: a multicenter study.
Trial report in Annals of medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
5 authors.
Funding
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Abstract
backgroundClear cell renal cell carcinoma (ccRCC) exhibits heterogeneous postoperative outcomes. This study aimed to evaluate systemic immunoinflammatory biomarkers and pathological features and develop an integrated prognostic model for overall survival (OS) in patients with ccRCC.
methodsThis multicenter retrospective study initially screened 1,662 patients who underwent surgery between January 2010 and December 2024. After excluding 27 patients with substantial missing data, 1,635 were included in baseline analyses, of whom 1,429 with complete data were included in prognostic modeling. Candidate predictors identified by univariable Cox regression were selected using elastic net regression and subsequently evaluated by multivariable Cox regression. Model performance was assessed using the C-index, time-dependent area under the curve (AUC), calibration curves, and decision curve analysis.
resultsSixteen variables with
conclusionsAn internally evaluated nomogram integrating systemic inflammatory indices and pathological features demonstrated good prognostic performance for OS in patients with ccRCC.
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