ArticleCureus2026
Acute EBV-Associated Systemic Inflammatory Syndrome Presenting as PUO With FDG-Avid Generalized Lymphadenopathy, Autoimmune Serological Positivity and Myopericarditis Mimicking Lymphoma and Connective Tissue Disease: A Diagnostic Challenge.
Article in Cureus, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Pyrexia of unknown origin (PUO) remains a diagnostic challenge, particularly when associated with lymphadenopathy, multisystem involvement and positive autoimmune serology. Distinguishing between infectious, inflammatory and malignant causes is often difficult, especially when advanced imaging demonstrates findings suggestive of lymphoma. A previously healthy man in his late 40s presented with a 10-day history of intermittent fever, myalgia, joint stiffness and pleuritic chest pain. During admission, he developed photophobia, mild neck stiffness, progressive upper and lower limb pain and weakness resulting in impaired mobility. Investigations demonstrated marked systemic inflammation with a C-reactive protein (CRP) of 235 mg/L and an erythrocyte sedimentation rate (ESR) of 105 mm/hr despite a normal white cell count (WCC). Extensive microbiological investigations including blood cultures, cerebrospinal fluid analysis, bacterial and fungal molecular testing, tuberculosis screening and viral polymerase chain reaction (PCR) testing were negative apart from detectable Epstein-Barr virus (EBV) DNA and positive EBV IgM serology. Autoimmune screening revealed positive ANA, anti-Ro52, anti-Ro60 and anti-La antibodies with low complement C4. Cardiac magnetic resonance imaging (MRI) confirmed acute myopericarditis. Positron emission tomography
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.