ArticlePakistan journal of medical sciences2026
Evaluation of serum antioxidant markers and calcium levels in women with Arthritis.
Article in Pakistan journal of medical sciences, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background & Objective: Osteoarthritis (OA) and Rheumatoid Arthritis (RA) are chronic, degenerative and inflammatory joint diseases, aggravated by reactive oxygen species (ROS) and impaired antioxidant defense system. However, gender based oxidative stress analysis remain under-examined, despite increasing evidence points towards sex-based biochemical changes in arthritis patients. The study aimed to measure the antioxidant activities of enzymes including superoxide dismutase (SOD), Glutathione reductase (GR) alongside reduced glutathione (GSH), and catalase (CAT) in female arthritis patients. Calcium balance is also estimated in order to analyze the bone demineralization. Methodology: The case-control study was designed and conducted at the Orthopedic Department of a Dr. Ruth K. M. Pfau, Civil hospital, Karachi. Serum levels of GSH, GR, SOD, CAT, and calcium were evaluated in 42 arthritis patients and 16 age matched healthy female controls by using standard spectrophotometric and biochemical assays. Data was expressed as mean ± SD and analyzed statistically to compare both the groups. Results: Arthritis patients in comparison with healthy controls showed significant decrease in GSH (p < 0.001) and GR (p < 0.01) levels, while SOD and CAT levels were slightly reduced but non-significant. Similarly, slightly higher calcium levels were also observed, suggesting altered mineral homeostasis associated with inflammatory conditions. The simultaneous decrease in antioxidant enzyme activities suggests the impaired redox homeostasis in female patients. Conclusion: The study highlights an altered antioxidant status and disturbed calcium homeostasis in female patients. These alterations in biochemical system suggest the therapeutic potential of antioxidant and calcium modulating interventions as effective treatment for managing and slowing disease progression in females.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.