Evidence map›Paper›PMID 42668854›Full record

ArticleInternational journal of general medicine2026

Diagnostic Performance of Platelet-to-Lymphocyte Ratio and CA19-9 Added to EUS-FNA for Solid Pancreatic Lesions: A Single-Center Retrospective Study.

Shasha Liu, Chen Hu, Yujing Fan, Lina Liu, Ying Hu

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Article in International journal of general medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

5 authors.

Shasha LiuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Chen HuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Yujing FanDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Lina LiuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.
Ying HuDepartment of Gastroenterology and Hepatology, The Second Affiliated Hospital of Harbin Medical University, Harbin, Heilongjiang, People's Republic of China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Purpose: To evaluate the incremental diagnostic value of the platelet-to-lymphocyte ratio (PLR) and carbohydrate antigen 19-9 (CA19-9) when combined with endoscopic ultrasound-guided fine-needle aspiration (EUS-FNA) in patients with solid pancreatic lesions. Patients and Methods: This retrospective single-center study included 127 consecutive patients who underwent EUS-FNA for solid pancreatic lesions between December 29, 2020, and October 23, 2023. Final diagnoses were established using a reference standard independent of the index EUS-FNA. Malignancy was confirmed by surgical pathology, independent cytologic or histologic evidence, or unequivocal radiologic progression or metastasis. Non-malignancy was established by independent benign pathology or lesion stability or regression without anticancer therapy during at least 24 months of clinical and imaging follow-up. Results: Among 127 patients, 80 had malignant lesions and 47 had non-malignant lesions. EUS-FNA achieved an accuracy of 91.3%, sensitivity of 93.8%, specificity of 87.2%, positive predictive value of 92.6%, and negative predictive value of 89.1%. CA19-9 levels were significantly higher in malignant than in non-malignant lesions (median [IQR], 197.21 [9.51-928.36] vs 14.30 [3.97-211.02] U/mL; Conclusion: EUS-FNA demonstrated high diagnostic accuracy for solid pancreatic lesions. PLR and CA19-9 provided complementary diagnostic value, and the three-variable model showed high diagnostic performance after internal validation.

Indexed as

carbohydrate antigen 19-9diagnostic accuracyendoscopic ultrasound-guided fine-needle aspirationplatelet-to-lymphocyte ratiosolid pancreatic lesions

Identifiers

PMID42668854
PMCPMC13525798

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.