Evidence map›Paper›PMID 42668827›Full record

ArticleTherapeutic advances in musculoskeletal disease2026

Diagnostic performance of salivary gland ultrasonography using the OMERACT scoring system in Sjögren disease: A cross-sectional diagnostic accuracy study.

Md Ismail Hossain, Minhaj Rahim Choudhury, Muhammad Shoaib Momen Majumder, Md Nahiduzzamane Shazzad, Mohammad Abul Kalam Azad, Md Masudul Hassan, Rijwan Bhuiyan, Md Shohel Hasan

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Article in Therapeutic advances in musculoskeletal disease, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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4 · The record

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5 · Who and what money

Authors and funding

8 authors.

Md Ismail HossainDepartment of Rheumatology, Rajshahi Medical College, Rajshahi, Bangladesh.ORCID https://orcid.org/0000-0002-9400-8315
Minhaj Rahim ChoudhuryDepartment of Rheumatology, Bangladesh Medical University, Dhaka, Bangladesh.
Muhammad Shoaib Momen MajumderDepartment of Rheumatology, Bangladesh Medical University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0002-7901-0847
Md Nahiduzzamane ShazzadDepartment of Rheumatology, Bangladesh Medical University, Dhaka, Bangladesh.
Mohammad Abul Kalam AzadDepartment of Rheumatology, Bangladesh Medical University, Dhaka, Bangladesh.ORCID https://orcid.org/0009-0009-0797-2340
Md Masudul HassanDepartment of Rheumatology, Bangladesh Medical University, Dhaka, Bangladesh.
Rijwan BhuiyanDepartment of Public Health and Informatics, Bangladesh Medical University, Dhaka, Bangladesh.ORCID https://orcid.org/0000-0003-0005-8889
Md Shohel HasanDepartment of Rheumatology, Rajshahi Medical College, Rajshahi, Bangladesh.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Background: Sjögren disease (SjD) is an autoimmune disorder characterized by salivary and lacrimal gland dysfunction. Salivary gland ultrasonography (SGUS) is a non-invasive, accessible imaging modality for assessing glandular structural changes, although its diagnostic performance compared with conventional diagnostic tests requires further evaluation. Objectives: To evaluate the diagnostic accuracy of OMERACT-scored salivary gland ultrasonography in patients with suspected primary or secondary SjD. Design: This is a cross-sectional diagnostic accuracy study of salivary ultrasonography. Methods: This study was conducted in the Department of Rheumatology, Bangladesh Medical University, from February 2023 to February 2024. Patients presenting with sicca symptoms were classified according to the 2016 ACR/EULAR classification criteria, which served as the reference standard. All participants underwent clinical evaluation, Schirmer's test, unstimulated whole salivary flow rate (UWSFR), anti-SSA/anti-SSB antibody testing, and SGUS of the parotid and submandibular glands. SGUS images were scored using the OMERACT semiquantitative grayscale scoring system (0-3 per gland) by a blinded examiner. Diagnostic performance was assessed using sensitivity, specificity, and receiver operating characteristic (ROC) curve analysis. Results: Among 100 participants, 50 fulfilled the 2016 ACR/EULAR classification criteria for SjD. Patients with SjD had significantly higher mean SGUS scores and lower mean UWSFR compared with those without SjD ( Conclusion: OMERACT-scored salivary gland ultrasonography demonstrated excellent diagnostic accuracy and superior specificity compared with conventional functional tests. SGUS may serve as a valuable non-invasive adjunctive tool in the diagnostic evaluation of patients with suspected SjD.

Indexed as

diagnostic accuracyOMERACTsalivary gland ultrasonographySchirmer’s testSjögren diseaseunstimulated whole salivary flow rate

Identifiers

PMID42668827
PMCPMC13525324

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