ReviewCaspian journal of internal medicine2026
The signaling pathway of PPAR-γ and its protective role in various diseases.
Review in Caspian journal of internal medicine, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The peroxisome proliferator-activated receptor gamma (PPARγ) signaling pathway is one of the most important physiological pathways in the body, which is known for its beneficial role in regulating metabolism and modulating disease processes. This ligand-activated nuclear receptor significantly influences glucose and lipid metabolism, and is involved in various cellular functions, including anti-inflammatory, antioxidant, and anti-apoptotic responses. PPARγ activity can be regulated through multiple post-translational modifications such as acetylation, glycosylation, and phosphorylation, which underscores its complexity and therapeutic potential. In this review, we examined numerous studies investigating the role of the PPAR-γ signaling pathway in a wide range of diseases. Particular emphasis was placed on its involvement in the cardiovascular system, central nervous system (CNS), digestive system, respiratory as well as urinary systems, and allergic diseases. Accumulating evidence has shown that activation of this pathway can modulate inflammatory and oxidative responses, enhance insulin sensitivity, and provide neuroprotective and organ-protective effects. To conduct this review, we searched PubMed, Web of Science, EBSCO, Scopus, Google Scholar, Directory of Open Access Journals (DOAJ), and Embase, using keywords such as "PPAR-γ," "Signaling Pathway," "Anti-inflammatory," "Antioxidant," and "Diseases." These searches revealed consistent findings supporting the therapeutic potential of PPARγ activation in diverse pathological conditions. The evidence suggests that targeting the PPARγ pathway may offer novel strategies for preventing and treating a variety of metabolic, inflammatory and degenerative diseases.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.