ArticleFoot & ankle orthopaedics2026
Association Between Hypothyroidism and Postoperative Complications Following Operative Ankle Fracture Fixation: A Retrospective Cohort Study.
Article in Foot & ankle orthopaedics, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Background: Hypothyroidism has been associated with altered bone metabolism, impaired mineralization, and increased fracture risk, but its relationship with postoperative complications after operative ankle fracture fixation remains poorly defined. This study evaluated whether preexisting hypothyroidism is associated with increased complications following surgical treatment of ankle fractures. Methods: Adults undergoing operative ankle fracture fixation or related ankle fracture surgery in TriNetX were stratified by hypothyroidism diagnosed within 6 months before or on surgery vs no recorded hypothyroidism history. Propensity score matching was performed 1:1 using demographic factors, diagnosis-coded obesity/overweight, hemoglobin A Results: After matching, 10 406 patients per cohort were included in the 3- and 6-month analyses, and 10 407 per cohort were included at 1 year. With the numbers available, no significant difference could be detected for any 3-month outcome. At 6 months, nonunion/malunion (RR, 1.305; 95% CI, 1.065-1.600; RD Conclusion: In this propensity-matched retrospective cohort study, preexisting hypothyroidism was associated with modest but statistically significant increases in delayed osseous and hardware-related complications after operative ankle fracture surgery ( Level of Evidence: Level III, retrospective cohort study.
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