Evidence map›Paper›PMID 42668664›Full record

ArticleiScience2026

Uridine and pyruvate supplementation is associated with Th1 polarization during mitotoxic antibiotic therapy.

Stefania De Santis, Monica Rutigliano, Federica Simone, Letizia Larocca, Maria Laura Matrella, Martina Milella, Antonio Vavallo, Pasquale Ditonno, Nicola Marrano, Anna Mestice and 6 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors.

Stefania De SantisDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Monica RutiglianoDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Federica SimoneDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Letizia LaroccaDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Maria Laura MatrellaDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Martina MilellaDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Antonio VavalloDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Pasquale DitonnoDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Nicola MarranoDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Anna MesticeDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Stefano BattagliaDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Michele BattagliaDepartment of Precision and Regenerative Medicine and Ionian Area, University of Bari Aldo Moro, Bari, Italy.
Antonio MoschettaDepartment of Interdisciplinary Medicine, University of Bari Aldo Moro, Bari, Italy.
Peter SeibelMolecular Cell Therapy, BBZ, Medical Faculty, University of Leipzig, Leipzig, Germany.
Elena PiccininDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.
Gaetano VillaniDepartment of Translational Biomedicine and Neuroscience, University of Bari Aldo Moro, Bari, Italy.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Antibiotics with off-target mitochondrial toxicity can impair host immunity, yet their impact on human adaptive immunity

Indexed as

antibioticsGDF15immunometabolismmitochondriaOXPHOSpyruvateT cellsuridine

Identifiers

PMID42668664
PMCPMC13524768

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.