Evidence map›Paper›PMID 42668630›Full record

ArticleiScience2026

Single-cell transcriptomic signatures of T cells associated with rituximab responsiveness in idiopathic nephrotic syndrome.

Eri Koshi-Ito, Yu Watanabe, Chikao Onogi, Asuka Horinouchi, Koichi Ogami, Seiko Yoshino, Yohei Sugimoto, Shintaro Komatsu, Akihito Tanaka, Kazuhiro Furuhashi and 2 more

Abstract read
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In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Eri Koshi-ItoDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Yu WatanabeDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Chikao OnogiDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Asuka HorinouchiDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Koichi OgamiDivision of Molecular Oncology, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Seiko YoshinoDivision of Molecular Oncology, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Yohei SugimotoDivision of Molecular Oncology, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Shintaro KomatsuDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Akihito TanakaDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Kazuhiro FuruhashiDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Shoichi MaruyamaDepartment of Nephrology, Internal Medicine, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.
Hiroshi I SuzukiDivision of Molecular Oncology, Center for Neurological Diseases and Cancer, Graduate School of Medicine, Nagoya University, Nagoya 466-8550, Japan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Rituximab (RTX) is increasingly used in steroid-dependent minimal change disease, a leading cause of idiopathic nephrotic syndrome (INS), yet predictors of response remain unclear. Although RTX primarily targets B cells, T cells are also implicated in INS pathogenesis. We investigated RTX-induced T cell dynamics by single-cell RNA sequencing/T cell receptor profiling of peripheral T cells from three responders and three non-responders before and after RTX treatment. Responders exhibited RTX-driven broad transcriptomic remodeling, accompanied by reduced exhausted CD8

Indexed as

idiopathic nephrotic syndromeoxidative phosphorylationreactive oxygen speciesrituximabsingle-cell RNA sequencingT cells

Identifiers

PMID42668630
PMCPMC13524719

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.