Evidence map›Paper›PMID 42668625›Full record

ArticleiScience2026

Intrinsic anti-tumorigenic properties of the skin epithelium promote cancer resistance in naked mole-rats.

Iqra Fatima, Andrei N Mardaryev, Elena Rozhkova, Natalia V Botchkareva, Andrey A Sharov, Vladimir A Botchkarev

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Iqra FatimaDepartment of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.
Andrei N MardaryevCentre for Skin Sciences, Faculty of Life Sciences, University of Bradford, Bradford, UK.
Elena RozhkovaDepartment of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.
Natalia V BotchkarevaDepartment of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.
Andrey A SharovDepartment of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.
Vladimir A BotchkarevDepartment of Dermatology, Boston University School of Medicine, 609 Albany Street, Boston, MA 02118, USA.

Funding

The skin of naked mole rats as a model for scar-free wound healingR33AR078093 · NIAMS · BOSTON UNIVERSITY MEDICAL CAMPUS · PI BOTCHKAREV, VLADIMIR A, GORBUNOVA, VERA · 2023 to 2023
$406k
NIAMS NIH HHS R33 AR078093
6 · The paper itself

Abstract

Naked mole-rats (NMRs) are unique long-lived mammals that possess marked resistance to cancer including lack of any reported spontaneous skin cancer incidences. Here, we show that in comparison with mice, homeostatic epidermal keratinocytes in NMRs exhibit elevated expression of 324 tumor suppressor genes of different classes including 55 genes regulating DNA damage/repair. Furthermore, NMR skin grafted onto

Indexed as

cancerDNA repairkeratinocytenaked mole-ratoncogeneskintumor suppressor

Identifiers

PMID42668625
PMCPMC13524728

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.