Porphyrin-copper (II) covalent organic framework nanoplatform with intrinsic bifunctional photodynamic and chemodynamic activities for synergistic multimodal cancer therapy.

Yongjie Mo, Jie Hou, Hongli Li, Lijuan Wang, Linlu Zhao, Linhua Zhu, Chunyan Dai

Abstract read

In one paragraph

Article in Materials today. Bio, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Yongjie MoKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Jie HouKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Hongli LiKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Lijuan WangKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Linlu ZhaoKey Laboratory of Emergency and Trauma of the Ministry of Education, The First Affiliated Hospital, Hainan Medical University, Haikou, 571199, China.

Linhua ZhuKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Chunyan DaiKey Laboratory of Tropical Medicinal Resource Chemistry of Ministry of Education, Key Laboratory of Tropical Medicinal Plant Chemistry of Hainan Province, The International Joint Research Center for Clean and Efficient Utilization of Hydrocarbon Resources in the South China Sea of Hainan Province, Engineering Research Center of Tropical Marine Functional Polymer Materials of Hainan Province, Key Laboratory of Water Pollution Treatment and Resource Reuse of Hainan Province, Key Laboratory of Functional Organic Polymers of Haikou, Hainan Normal University, Haikou, 571158, China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Photodynamic therapy (PDT) efficacy is severely compromised by tumor hypoxia and the scarcity of efficient type-I photosensitizers, necessitating multimodal therapeutic strategies. Herein, we report a porphyrin-Cu (II) covalent organic framework (TBCOF) with intrinsic bifunctional photodynamic and chemodynamic activities. Sequential DOX encapsulation and hyaluronic acid (HA) surface functionalization afford HA-TBCOF@DOX, a tumor-targeted nanoplatform integrating four synergistic therapeutic modalities. Under 660 nm laser irradiation, the nanoplatform generates ROS signatures consistent with both type-I and type-II pathways for PDT, while the intrinsic Cu

Indexed as

Chemodynamic therapyCovalent organic frameworkMultimodal cancer therapyPhotodynamic therapyPorphyrin

Identifiers

PMID42668618

DOI10.1016/j.mtbio.2026.103579

PMCPMC13524741

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.