Evidence map›Paper›PMID 42668608›Full record

ArticleiScience2026

CLEC-1 promotes early IFN response in cDC1s and favors immune dysregulation during sepsis in mice.

Thomas Teja Ogor, Esther Porée, Javier Saenz, Marion Davieau, Victor Gourain, Camille Ligeron, Florian Pierre Martin, Cynthia Fourgeux, Claire Chédeville, Julie Mignon and 10 more

Abstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors.

Thomas Teja OgorNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Esther PoréeNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Javier SaenzNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Marion DavieauNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Victor GourainNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Camille LigeronNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Florian Pierre MartinNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Cynthia FourgeuxNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Claire ChédevilleNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Julie MignonNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Martin BraudNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Aurélie MoreauNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Régis JosienNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Aurore MorelloOse Immunotherapeutics, Nantes, France.
Etienne FoucherOse Immunotherapeutics, Nantes, France.
Nicolas PoirierOse Immunotherapeutics, Nantes, France.
Jeremie PoschmannNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Antoine RoquillyNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Cédric JacquelineNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.
Elise ChiffoleauNantes Université, INSERM, Center for Research in Transplantation and Translational Immunology, UMR 1064, 44000 Nantes, France.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Sepsis is a life-threatening organ dysfunction caused by a dysregulated host immune response, characterized by both hyperinflammation and immunosuppression. Here, we show that the absence of the C-type lectin receptor CLEC-1-expressed particularly by lung cDC1s-improves mouse recovery following

Indexed as

chemokinesimmunotherapyinflammationmonocytes/macrophagesneutrophilsrodent

Identifiers

PMID42668608
PMCPMC13524758

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.