ArticleiScience2026
Gut microbiota and uric acid excretion signaling in pathogenesis of hyperuricemia and acute gouty arthritis.
Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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13 authors.
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Abstract
Hyperuricemia (HUA) and acute gouty arthritis (AGA) represent distinct pathological stages of gout, with the intestine playing a critical role in uric acid (UA) excretion. By establishing HUA and AGA mouse models, we observed both induced renal and intestinal pathology, elevated inflammatory factors, reduced expression of barrier proteins (Occludin, Claudin-1, and Zonula occludens-1 [ZO-1]), increased permeability markers (DAO and D-LA), upregulation of GLUT9, downregulation of ABCG2, and more severe pathology in AGA. 16S rRNA sequencing revealed alterations in gut microbial composition, with 11 bacterial genera overlapping between the 2, including
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