Evidence map›Paper›PMID 42668535›Full record

ArticleiScience2026

Claudin-12 sustains urothelial barrier defense against uropathogenic

Yanpeng Tian, Hongping Tong, Yinhui Sun, Longcheng Hong, Xiaoming Lei, Feng Wang

Abstract read
In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors.

Yanpeng TianMedical School, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan 410208, P.R. China.
Hongping TongDepartment of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, No. 100, Minjiang Road, Quzhou, Zhejiang 324000, P.R. China.
Yinhui SunMedical School, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan 410208, P.R. China.
Longcheng HongInstitute of Zhejiang University-Quzhou, No. 99 Zheda Road, Quzhou, Zhejiang 324000, P.R. China.
Xiaoming LeiMedical School, Hunan University of Chinese Medicine, No. 300 Xueshi Road, Changsha, Hunan 410208, P.R. China.
Feng WangDepartment of Ophthalmology, The Quzhou Affiliated Hospital of Wenzhou Medical University, Quzhou People's Hospital, No. 100, Minjiang Road, Quzhou, Zhejiang 324000, P.R. China.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Urothelial barrier compromise defines inflammatory cystitis, though molecular regulators remain elusive. We identify claudin-12-a bladder-enriched tight junction protein-as an essential barrier component against uropathogenic

Indexed as

calcium-dependentclaudin-12immunomodulationtight junctionUPEC

Identifiers

PMID42668535
PMCPMC13524722

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.