Evidence map›Paper›PMID 42668334›Full record

ArticleMolecular neurobiology2026

Cottonseed Oil Attenuates Traumatic Brain Injury by Inhibiting AKT/GSK-3β-mediated Neuroinflammatory Responses.

Min Liu, Yafan Bai, Yue Zhang, Yimeng Chen, Wenjia Shen, Ruirong Chen, Tiantian Liu, Lili Wu, Chunhua Xi, Siyuan Liu and 2 more

Abstract read
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Article in Molecular neurobiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Min Liu *Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Yafan Bai *Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Yue Zhang *Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Yimeng ChenDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Wenjia ShenDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Ruirong ChenDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Tiantian LiuDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Lili WuDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Chunhua XiDepartment of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China.
Siyuan Liu *Department of Anesthesiology, Affiliated Hospital of Nantong University, Nantong, 226001, China. jssylsy@126.com.
Yulong Ma *Department of Anesthesiology, The First Medical Center of Chinese, PLA General Hospital, Beijing, 100853, China. yulongma123@163.com.
Guyan Wang *Department of Anesthesiology, Beijing Tongren Hospital, Capital Medical University, Beijing, 100730, China. Guyanwang2006@163.com.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Traumatic brain injury (TBI) is a major cause of long-term neurological disability worldwide, and effective therapeutic strategies remain limited. Cottonseed oil (CSO), a plant-derived oil rich in polyunsaturated fatty acids, has been reported to exert protective effects in ischemia-related injuries; however, its role and underlying mechanisms in TBI remain unclear. Here, we established a controlled cortical impact (CCI) model in mice and administered CSO by oral gavage prior to injury. Neurological function was assessed using the modified neurological severity score, rotarod, and balance beam tests, and neuronal injury was evaluated by histological and biochemical analyses. CSO administration significantly improved neurological and motor function, attenuated neuronal damage and apoptosis, enhanced cerebral blood perfusion, preserved blood-brain barrier (BBB) integrity, and reduced brain edema. CSO modulated the expression of AQP4, VEGFA, and BDNF, and markedly suppressed glial activation and pro-inflammatory cytokine production. In vitro, CSO alleviated H

Indexed as

Brain Injuries, TraumaticCottonseed OilGlycogen Synthase Kinase 3 betaNeuroinflammatory DiseasesProto-Oncogene Proteins c-aktAnimalsBlood-Brain BarrierCell LineMaleMiceMice, Inbred C57BLNeuronsNeuroprotective AgentsSignal TransductionCottonseed OilGlycogen Synthase Kinase 3 betaNeuroprotective AgentsProto-Oncogene Proteins c-aktAKT/GSK-3βCottonseed oil (CSO)NeuroinflammationNeuroprotectionTraumatic brain injury (TBI)

Identifiers

PMID42668334

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.