Evidence map›Paper›PMID 42668310›Full record

ArticleInternational journal of obesity (2005)2026

CFTR regulates lipid metabolism by relieving adipose inflammation in obesity.

Jieyi Du, Chuanfeng Ke, Jingbo Chen, Mei Li, Yang Zhao, Ping Pan, Shuijie Li, Wenming Xu, Ricardo Azziz, Guanlei Wang and 1 more

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Article in International journal of obesity (2005), 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Jieyi Du *Department of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China.
Chuanfeng Ke *Department of Gastrointestinal Surgery, the first affiliate hospital of Guangzhou Medical University, Guangzhou, China.
Jingbo Chen *Department of Reproductive Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Mei Li *VIP Healthcare Center, the Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.
Yang ZhaoDepartment of Reproductive Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China.
Ping PanDepartment of Obstetrics and Gynecology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Shuijie LiDepartment of Biopharmaceutical Sciences, College of Pharmacy, Harbin Medical University, Harbin, China.
Wenming XuJoint Laboratory of Reproductive Medicine, SCU-CUHK, Key Laboratory of Obstetric, Gynaecologic and Paediatric Diseases and Birth Defects of Ministry of Education, West China Second University Hospital, Sichuan University, Chengdu, China.
Ricardo AzzizDepartments of Obstetrics and Gynaecology, and Medicine, Heersink School of Medicine, University of Alabama at Birmingham, Birmingham, AL, USA.
Guanlei WangDepartment of Pharmacology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China. wangglei@mail.sysu.edu.cn.
Xiaomiao ZhaoDepartment of Reproductive Medicine, Guangdong Provincial People's Hospital (Guangdong Academy of Medical Sciences), Southern Medical University, Guangzhou, China. zhaoxiaomiao@gdph.org.cn.ORCID http://orcid.org/0000-0003-1962-3833

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

purposeThe downregulation of the cystic fibrosis transmembrane conductance regulator (CFTR) reduces lipogenesis and alters lipid metabolism. However, the role of CFTR in inflammation regulation in adipose tissue has been unknown. This study aims to explore the role of CFTR in adipose inflammation and lipid metabolism and the underlying mechanism using both in vivo and in vitro models.

methodsWe observed the changes in CFTR levels in human adipose tissue, a diet-induced obesity (DIO) mouse model, and 3T3-L1 cells and explored the relationship between CFTR and adipose inflammation.

resultsThe mRNA expression of CFTR in human omental adipose tissue firstly rose with the BMI and WHR increasing, reached the peak at a BMI of 25-27 kg/m

conclusionsCFTR plays a critical role in adipose inflammation regulation and it also represents a potential therapeutic target for the regulation of adipose inflammation and obesity.

Identifiers

PMID42668310

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