ArticleOral radiology2026
Positron emission tomography/computed tomography radiomics-based prediction of cervical nodal metastasis in patients with tongue squamous cell carcinoma.
Article in Oral radiology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
objectivesTo develop and validate a logistic regression model that integrates clinical and fluorodeoxyglucose positron emission tomography/computed tomography (FDG-PET/CT)-derived radiomic features to predict cervical lymph node metastasis in tongue squamous cell carcinoma.
methodsThis retrospective study included 316 patients who underwent preoperative FDG-PET/CT between December 2013 and December 2023, classified into analysis (n = 250) and validation (n = 66) cohorts. Primary tumours were segmented using standardised uptake value (SUV)-based thresholds (≥ 40% of SUVmax). Metabolic parameters such as SUVmax and 107 radiomic features were extracted. Significant variables in the univariate analysis were analysed using multivariable logistic regression. Model performance was assessed using receiver operating characteristic analysis, with the predicted probability (PP) cut-off optimised using Youden's index. Diagnostic performance was compared with lymph node SUVmax and expert visual assessments.
resultsFour independent predictors-clinical growth pattern, SUVpeak, grey level co-occurrence matrix inverse difference moment normalised, and grey level size zone matrix low grey-level zone emphasis-were included in the final model. In the analysis cohort, the model achieved an area under the curve (AUC) of 0.88, sensitivity of 0.84, and specificity of 0.79 at an optimal PP cut-off of 0.34. AUCs for lymph node SUVmax and expert visual interpretation were 0.76 and 0.79, respectively. In external validation, accuracy was 0.80 versus 0.68 for visual assessment.
conclusionsA transparent logistic regression model integrating clinical growth patterns and FDG-PET/CT metabolic and radiomic features demonstrated high discrimination and maintained favourable accuracy in external validation, supporting its potential use in individualised preoperative risk stratification.
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