Evidence map›Paper›PMID 42667506›Full record

ArticleVeterinary research communications2026

Genomic analysis of Escherichia coli, Enterobacter hormaechei, and Cupriavidus gilardii isolated from Cacatua alba.

Julia Penna de Andrade, Henrique da Silva Vieira, Camilla Faria Soares, Marcela Laryssa Oliveira Duarte, André Almeida Fernandes, Hannah Luiza Gonsalves Coelho, Victória Veiga Alves, Bertram Brenig, Vasco Ariston de Carvalho Azevedo, Flávia Figueira Aburjaile and 1 more

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Article in Veterinary research communications, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

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3 · Its place in the literature

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4 · The record

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5 · Who and what money

Authors and funding

11 authors.

Julia Penna de AndradeDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil. juliapenna.vet@gmail.com.
Henrique da Silva VieiraDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Camilla Faria SoaresDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Marcela Laryssa Oliveira DuarteDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
André Almeida FernandesDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Hannah Luiza Gonsalves CoelhoDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Victória Veiga AlvesDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Bertram BrenigInstitute of Veterinary Medicine, University Göttingen, Göttingen, 37077, Germany.
Vasco Ariston de Carvalho AzevedoDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Flávia Figueira AburjaileDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.
Nelson Rodrigo da Silva MartinsDepartamento de medicina veterinária preventiva, Universidade Federal de Minas Gerais, Belo Horizonte, Brasil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The objective of this study was to perform genomic, phylogenomic, and phenotypic characterization of bacterial isolates from a captive Cacatua alba to investigate their antimicrobial resistance profiles, virulence-associated genes, and genomic relationships with publicly available strains. Bacterial isolates obtained from the lungs and encephalon were identified as Escherichia coli (AV037), Enterobacter hormaechei (AV038), and Cupriavidus gilardii (AV039). Comparative genomic analyses, phylogenomic reconstruction, and antimicrobial susceptibility testing (AST) were performed. Genomic analysis identified multiple antimicrobial resistance-associated genes in AV037, AV038, and AV039, with genes associated with efflux pumps, particularly those in the resistance-nodulation-cell division (RND) family, as the predominant resistance-associated mechanism identified. Most identified genes are intrinsic to the respective bacterial species and do not necessarily confer phenotypic antimicrobial resistance when present alone. Phenotypic testing confirmed multidrug-resistant (MDR) profiles, with resistance to β-lactams and aminoglycosides. Susceptibility to carbapenems was preserved in AV037 and AV038, whereas AV039 exhibited resistance to meropenem. Phylogenomic analysis demonstrated that AV037 and AV038 clustered with strains recovered from diverse hosts and geographic regions. In contrast, AV039 clustered predominantly with environmental and human-associated isolates, including strains harboring the mcr-5 gene. These findings are consistent with previous reports describing the recovery of C. gilardii from both environmental and clinical sources. Overall, this study documents the occurrence of MDR bacteria carrying resistance and virulence-associated determinants in a captive C. alba, highlighting the value of genomic surveillance to improve our understanding of the distribution of clinically relevant bacterial isolates across different ecological settings.

Indexed as

CupriavidusEnterobacterEscherichia coliGenome, BacterialAnimalsAnti-Bacterial AgentsDrug Resistance, Multiple, BacterialGenomicsMicrobial Sensitivity TestsPhylogenyAnti-Bacterial AgentsNon-fermentative gram negative bacteriaOne HealthPathogen emergencePsittacidaeResistome

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.