Evidence map›Paper›PMID 42667465›Full record

ArticleMolecular biology reports2026

Identification of ZmGLN5, a candidate gene for resistance to Gibberella ear rot in maize.

Liang Ma, Lu Ma, Shuyu Zhang, Huimin Zhang, Xudong Song, Zhenliang Zhang, Yuxiang Mao, Huhua Lu, Guoqing Chen, Derong Hao and 1 more

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Article in Molecular biology reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

11 authors.

Liang MaJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Lu MaJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Shuyu ZhangJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Huimin ZhangJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Xudong SongJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Zhenliang ZhangJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Yuxiang MaoJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Huhua LuJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Guoqing ChenJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Derong HaoJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China.
Guangfei ZhouJiangsu Yanjiang Institute of Agricultural Sciences, Nantong, 226012, China. gfzhou88@jaas.ac.cn.ORCID https://orcid.org/0000-0002-0126-5030

Funding

the Natural Science Foundation of Jiangsu Province, China BK20241833the Natural Science Foundation of Jiangsu Province, China BK20250548the Natural Science Foundation of Nantong City, China JC2023048the Youth Doctoral Foundation of Jiangsu Yanjiang Institute of Agricultural Science, China YJBS(2023)004
6 · The paper itself

Abstract

backgroundGibberella ear rot (GER), caused by the fungal pathogen Fusarium graminearum (F. graminearum), severely affects maize yield and grain quality worldwide. Although numerous genetic loci associated with maize resistance to GER have been identified, the functional genes underlying resistance to GER remain largely uncharacterized. METHODS AND

resultsIn this study, we performed comparative transcriptome analysis using two maize lines with contrasting resistance to GER. Differently expressed genes were mainly involved in defense-related pathway, including phenylpropanoid biosynthesis, glutathione metabolism, flavonoid biosynthesis, and MAPK signaling pathway. By integrating weighted gene co-expression network analysis and meta-quantitative trait loci results, nine candidate genes for maize resistance to GER were identified. Among these candidates, ZmGLN5, which encodes glutamine synthetase 5, was further validated by gene-based association analysis and mutagenesis experiments. An insert/deletion marker was developed based on the natural variation in the first intron of ZmGLN5, and its genetic effect was validated in a panel of 150 maize inbred lines. In addition, ZmGLN5 may also play a regulatory role in kernel number per row and ear length in maize.

conclusionZmGLN5 has been characterized as a key candidate gene underlying maize resistance to GER. This finding provides valuable genetic resources for improving resistance to GER in maize breeding programs.

Indexed as

Disease ResistanceGibberellaGlutamate-Ammonia LigasePlant DiseasesZea maysFusariumGene Expression ProfilingGene Expression Regulation, PlantPlant ProteinsQuantitative Trait LociGlutamate-Ammonia LigasePlant Proteinscandidate geneGibberella ear rotglutamine synthetasemaizeweighted gene co-expression network analysis

Identifiers

PMID42667465

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