Evidence map›Paper›PMID 42667447›Full record

ArticleJournal of neuro-oncology2026

Radiological response of primary central nervous system lymphoma after corticosteroid therapy and its predictive value on overall survival: a multicenter study.

Florian Scheichel, D Pinggera, T Rossmann, B Popadic, S Aspalter, V Schön, A Woehrer, M M Dorostkar, C Dorfer, C F Freyschlag and 1 more

Abstract readMulticenter Study
PubMed Full text at PMC Publisher
In one paragraph

Article in Journal of neuro-oncology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors.

Florian ScheichelDepartment of Neurosurgery, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, Dunant-Platz 1, St. Pölten, 3100, Austria. florian.scheichel@stpoelten.lknoe.at.
D PinggeraDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
T RossmannDepartment of Neurosurgery, Neuromed Campus, Kepler University Hospital, Linz, Austria.
B PopadicDepartment of Neurosurgery, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, Dunant-Platz 1, St. Pölten, 3100, Austria.
S AspalterDepartment of Neurosurgery, Neuromed Campus, Kepler University Hospital, Linz, Austria.
V SchönDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
A WoehrerInstitute of Neuropathology and Neuro-Molecular-Pathology, Medical University, Innsbruck, Austria.
M M DorostkarInstitute of Clinical Pathology and Molecular Pathology of the Lower Austria Central Region, University Hospitals St. Pölten and Krems - NOE LGA, Karl Landsteiner University, St. Pölten, Austria.
C DorferDepartment of Neurosurgery, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, Dunant-Platz 1, St. Pölten, 3100, Austria.
C F FreyschlagDepartment of Neurosurgery, Medical University Innsbruck, Innsbruck, Austria.
F MarholdDepartment of Neurosurgery, University Hospital St. Pölten - NOE LGA, Karl Landsteiner University, Dunant-Platz 1, St. Pölten, 3100, Austria.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundPrimary Large-B-Cell Lymphoma of the CNS (PCNS-LBCL) is a rare, aggressive tumor often sensitive to corticosteroid therapy (CST). This multicenter study investigated the spectrum of radiological responses to routine CST and evaluated its impact on patient prognosis.

methodsThe researchers utilized a prospective cohort of 18 patients for volumetric MRI analysis and a combined prospective-retrospective cohort of 31 patients for 2D tumor analysis. Patients received CST post-biopsy, with follow-up MRIs performed on the seventh day (median) after surgery. The study correlated radiological responses with CST dosage, LDH levels, and overall survival (OS) using Kaplan-Meier and Firth-corrected Cox regression.

resultsIn the prospective cohort, 83.3% of tumors regressed with a median regression of 40%, while 16.7% progressed despite CST resulting in a median progression of 46%. These changes were not dose-dependent, but there were indications of a correlation with LDH levels. Patients showing regression had a median OS of 31.4 months, compared to 3.9 months for tumors progressing during CST (p = 0.015). Firth-corrected Cox regression showed, despite the small sample size, that radiological response (p = 0.02) could be a promising prognostic factor in a model including age, type of therapy and Karnofsky performance status.

conclusionThis study provides the first structured description of the range of radiological responses of PCNS-LBCL to CST. Furthermore, we found exploratory indications that radiological response to CST may predict outcome indicating shared sensitivity to other cytotoxic drugs. Further studies are necessary to fully understand diagnostic and prognostic implications of CST sensitivity in PCNS-LBCL and its underlying mechanisms.

Indexed as

Adrenal Cortex HormonesCentral Nervous System NeoplasmsLymphoma, Large B-Cell, DiffuseAdultAgedAged, 80 and overFemaleFollow-Up StudiesHumansKaplan-Meier EstimateMagnetic Resonance ImagingMaleMiddle AgedPrognosisProspective StudiesRetrospective StudiesAdrenal Cortex HormonesCorticosteroid therapyOverall survivalPrimary Large-B-Cell Lymphoma of the CNS

Identifiers

PMID42667447
PMCPMC13525931

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.