Evidence map›Paper›PMID 42667401›Full record

ArticleThe Journal of membrane biology2026

Effects of Cholesterol and Solution pH on Daptomycin-bilayer Interactions.

Samuel R Pennock, Maggie Cortes, Megha D Salecha, Neil X Sevilla, Nicole R Rementer, Kevin Rana, Luke C Hicks, Emmaleigh Fox, Ahmed Grine, Patience S Hammel and 3 more

Abstract read
In one paragraph

Article in The Journal of membrane biology, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it
0cells of the map it votes in
0citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Samuel R Pennock *Department of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Maggie Cortes *Department of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Megha D Salecha *Department of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Neil X SevillaDepartment of Biological & Biomedical Science, Rowan University, Glassboro, NJ, USA.
Nicole R RementerDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Kevin RanaDepartment of Biological & Biomedical Science, Rowan University, Glassboro, NJ, USA.
Luke C HicksDepartment of Biological & Biomedical Science, Rowan University, Glassboro, NJ, USA.
Emmaleigh FoxDepartment of Biological & Biomedical Science, Rowan University, Glassboro, NJ, USA.
Ahmed GrineDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Patience S HammelDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Timothy D VadenDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA.
Benjamin R CaroneDepartment of Biological & Biomedical Science, Rowan University, Glassboro, NJ, USA.
Gregory A CaputoDepartment of Chemistry & Biochemistry, Rowan University, Glassboro, NJ, USA. caputo@rowan.edu.ORCID https://orcid.org/0000-0002-4510-2815

Funding

U-Rise at Rowan UniversityT34GM136492 · NIGMS · ROWAN UNIVERSITY · PI KECK, THOMAS MCGOWAN, NUCCI, NATHANIEL V · 2021 to 2025
$2.0M
Development of novel, daptomycin-inspired antimicrobial peptides using non-canonical amino acidsR15AI188560 · NIAID · ROWAN UNIVERSITY · PI CAPUTO, GREGORY ALEXANDER · 2025 to 2025
$474k
NIAID NIH HHS R15 AI188560NIGMS NIH HHS T34 GM136492
6 · The paper itself

Abstract

The global challenge of increasing antibiotic resistance development has necessitated the continued development and investigation of novel and existing antimicrobials. Daptomycin is a cyclic lipopeptide isolated from Streptomyces roseosporus, which has been clinically approved to treat a variety of gram-positive infections. Daptomycin is a membrane-active antimicrobial peptide that requires Ca

Indexed as

Anti-Bacterial AgentsCholesterolDaptomycinLipid BilayersCalciumCell MembraneHydrogen-Ion ConcentrationAnti-Bacterial AgentsCalciumCholesterolDaptomycinLipid BilayersAntimicrobial peptidesDaptomycinFluorescenceModel membranes

Identifiers

PMID42667401
PMCPMC13526048

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.