Evidence map›Paper›PMID 42667328›Full record

ArticleSleep & breathing = Schlaf & Atmung2026

A hidden risk factor for residual mouth breathing in children after adenotonsillectomy: airborne allergen sensitization.

Zhilong Zeng, Ru Gao, Yu Chen, Shasha Huang, Jian Zhang, Zikang Xiao, Wei Li, Clifford Wang, Fang Wang, Tiansheng Wang

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Article in Sleep & breathing = Schlaf & Atmung, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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5 · Who and what money

Authors and funding

10 authors.

Zhilong ZengDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Ru GaoDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Yu ChenDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Shasha HuangDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Jian ZhangDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Zikang XiaoDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Wei LiDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China.
Clifford WangThe College of art and science, Ohio State University, 154 W. 12th Avenue, Columbus, OH, 43210, USA.
Fang WangDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China. 65988792@qq.com.
Tiansheng WangDepartment of Otorhinolaryngology Head and Neck Surgery, The Third Xiangya Hospital of Central South University, 138 Tongzipo Road, Yuelu District, Changsha, Hunan Province, China. tswheaven@hotmail.com.

Funding

the Natural Science Foundation of Changsha No. kq2202429the Natural Science Foundation of Hunan Province No. 2022JJ70153
6 · The paper itself

Abstract

backgroundMouth breathing (MB), a common manifestation of sleep-disordered breathing in children may induce craniofacial developmental abnormalities leading to adenoid facies. Although adenoidectomy and/or tonsillectomy (A&T) represents the primary therapeutic intervention, a substantial proportion of pediatric patients exhibit residual mouth breathing postoperatively. Why a substantial subset of children exhibit residual MB remains a critical clinical question. Among the overlooked explanations for this incomplete recovery may be sensitization to airborne allergens-a hidden determinant of postoperative outcomes. This study sought to define the role of this under-investigated risk factor in the failure to resolve MB following A&T.

methodsA retrospective analysis was conducted on a cohort of children who underwent A&T at our hospital from June 2023 to June 2024. Incomplete lip seal during sleep was used as the diagnostic criterion for mouth breathing. Allergic rhinitis and rhinosinusitis symptoms were quantified using the Total Nasal Symptom Score (TNSS). Preoperative serum allergen screening was performed in all cases. Multivariate analyses were employed to assess associations between postoperative mouth breathing resolution and age, gender, BMI, allergen sensitization and TNSS.

resultsThe study included 502 children. Residual mouth breathing was observed in 39.44% of cases. Atopy to airborne allergens was significantly correlated with surgical outcomes (P = 0.028), with house dust mites (HDM) sensitization exerting particularly strong effects (P = 0.002). Elevated TNSS scores for both allergic rhinitis (correlation coefficient R = 0.249) and rhinosinusitis (correlation coefficient R = 0.290) predicted diminished therapeutic response.

conclusionSensitization to airborne allergens, particularly HDM, is significantly associated with adverse mouth breathing resolution following A&T, suggesting it as a hidden associated factor for residual mouth breathing.

Indexed as

AdenoidectomyAllergensMouth BreathingPostoperative ComplicationsTonsillectomyChildChild, PreschoolFemaleHumansMaleRetrospective StudiesRisk FactorsAllergensAdenotonsillar hypertrophyAllergensMouth breathingSleep-disordered breathing

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.