ArticleJournal of food science2026
Dietary-Derived Corchorus olitorius L. Extract Suppresses KRAS-Mutant Pancreatic Cancer by Activating Ferritinophagy-Dependent Ferroptosis.
Article in Journal of food science, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
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Abstract
Pancreatic ductal adenocarcinoma (PDAC) is a highly aggressive malignancy characterized by frequent activating mutations in the Kirsten rat sarcoma viral oncogene homologue (KRAS) and limited therapeutic options. Corchorus olitorius L., a traditional edible plant widely consumed in Asia, possesses documented anti-inflammatory properties; however, its anticancer potential remains unclear. This study investigated whether Corchorus olitorius L. leaf extract (COE) induces ferroptosis in KRAS-mutant pancreatic cancer cells. The chemical composition of COE was characterized using high-performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry. A total of 11 compounds were identified, among which quercetin-3-O-glucoside was the most abundant. In our study, KRAS
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