ArticleNeuroimage. Reports2026
Regional cerebral FDG-PET metabolic patterns across severity of extracranial internal carotid artery stenosis.
Article in Neuroimage. Reports, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed.
No citing paper in PubMed yet.
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
11 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Background: Carotid stenosis is associated with stroke and cognitive impairment. Whether cerebral glucose hypometabolism, a marker for neurodegeneration, mediates the association between carotid stenosis and cognitive decline remains unclear. Objectives: To investigate whether carotid stenosis is associated with reduced cerebral glucose metabolism measured by Methods: We conducted a cross-sectional study of patients evaluated at Mayo Clinic (2010-2024) who underwent extracranial carotid imaging and brain Results: Among 84 patients, stenosis was mild in 86.9%, moderate in 4.8%, and severe in 8.3%; 44% underwent FDG-PET for clinical indications, mostly for suspected cognitive impairment. Increasing stenosis severity was associated with numerically lower metabolism in ipsilateral anterior circulation regions, without statistical significance. Adjusted odds of ipsilateral sensorimotor hypometabolism increased with stenosis severity (moderate: OR 2.90 [95%CI, 0.31-27.1]; severe: OR 5.56 [95% CI, 0.57-54.2]; P = 0.095), with attenuated associations in posterior circulation regions. Conclusion: FDG-PET demonstrated a numerical association between carotid stenosis severity and reduced cerebral glucose metabolism, but this did not reach statistical significance. Larger studies with greater representation of high-grade stenosis are needed.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.