Single-cell immune profiling of blood and thrombus in cancer-associated thrombosis.

Linlin Zhou, Yin Xia, Bingkun Chen, Xiaowen Lin, Hung-Chih Yang, Chen-Wei Yu

Abstract read

In one paragraph

Article in iScience, 2026. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

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0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

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3 · Its place in the literature

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0 citing papers in PubMed.

No citing paper in PubMed yet.

4 · The record

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5 · Who and what money

Authors and funding

6 authors.

Linlin ZhouInstitute of Immunotherapy, Fujian Medical University, Fuzhou, China.

Yin XiaDepartment of Vascular Surgery, the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Bingkun ChenInstitute of Immunotherapy, Fujian Medical University, Fuzhou, China.

Xiaowen LinDepartment of Vascular Surgery, the Affiliated People's Hospital of Fujian University of Traditional Chinese Medicine, Fuzhou, China.

Hung-Chih YangDepartment of Microbiology, National Taiwan University College of Medicine and Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan.

Chen-Wei YuDepartment of Statistics and Information Science, Fu Jen Catholic University, New Taipei City, Taiwan.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cancer-associated thrombosis (CAT) is a major cause of morbidity and mortality in patients with cancer, but the immune landscape of the thrombus itself is poorly mapped. We combined high-parameter mass cytometry of paired peripheral blood and venous thrombi from non-cancer deep vein thrombosis (DVT) and CAT with an integrated single-cell RNA-sequencing atlas to profile immune remodeling at single-cell resolution. Relative to non-cancer DVT, CAT thrombi showed expansion of CXCR3

Indexed as

cancer-associated thrombosisdeep vein thrombosissingle-cell immune profiling

Identifiers

PMID42667064

DOI10.1016/j.isci.2026.117151

PMCPMC13524497

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.